2. Gene
  3. GLS2 - glutaminase 2 Gene

GLS2 - glutaminase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GA; GLS; LGA; hLGA

Gene ID: 27165 | Gene type: protein coding

About GLS2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,470,952-56,488,161 (from NCBI)

This gene has 17 transcripts (splice variants), 252 orthologues and 1 paralogue. Biased expression in liver (RPKM 39.1), brain (RPKM 4.2) and 2 other tissues.

Summary

The protein encoded by this gene is a mitochondrial phosphate-activated Glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GLS2 Products(4)

mRNA Protein Name
NM_001280796.2 NP_001267725.1 glutaminase liver isoform, mitochondrial isoform 3
NM_001280797.2 NP_001267726.1 glutaminase liver isoform, mitochondrial isoform 4
NM_001280798.2 NP_001267727.1 glutaminase liver isoform, mitochondrial isoform 4
NM_013267.4 NP_037399.2 glutaminase liver isoform, mitochondrial isoform 1 precursor

GLS2 Protein Structure

Glutaminase

Glutaminase: Glutaminase (177 - 463)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (490 - 575)

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  • 602 a.a.
Protein Preferred Names Protein Names

glutaminase liver isoform, mitochondrial

L-glutamine amidohydrolase

Related Diseases

Diseases Alias
Juvenile Dermatitis Herpetiformis
Metabolic Acidosis
Sclerosing Keratitis

Sclerokeratitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-103671A IPN60090 dihydrochloride Inhibitor 99.05% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103671 IPN60090 Inhibitor 99.47% Unkown
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-12248A Telaglenastat hydrochloride / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GLS2 VGNC VGNC:29420
Canis familiaris GLS2 VGNC VGNC:41277
Mus musculus GLS2 MGD MGI:2143539
Felis catus GLS2 VGNC VGNC:62595
Macaca mulatta GLS2 VGNC VGNC:73035
Rattus norvegicus GLS2 RGD RGD:620359