PSMA4 - proteasome 20S subunit alpha 4 Gene

Also Known as HC9; PSC9; HsT17706

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5685

About PSMA4

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,540,405-78,552,417 (from NCBI)

This gene has 21 transcripts (splice variants), 245 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 63.8), lymph node (RPKM 63.8) and 25 other tissues.

Summary

This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]

PSMA4 Products (6)

mRNA Protein Name
NM_001102667.2 NP_001096137.1 proteasome subunit alpha type-4 isoform 1
NM_001102668.3 NP_001096138.1 proteasome subunit alpha type-4 isoform 2
NM_001330673.2 NP_001317602.1 proteasome subunit alpha type-4 isoform 3
NM_001330675.2 NP_001317604.1 proteasome subunit alpha type-4 isoform 4
NM_001330676.2 NP_001317605.1 proteasome subunit alpha type-4 isoform 1
NM_002789.6 NP_002780.1 proteasome subunit alpha type-4 isoform 1

PSMA4 Protein Structure

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (5 - 27)

Proteasome

Proteasome: Proteasome subunit (30 - 215)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

proteasome subunit alpha type-4

  • macropain subunit C9

PSMA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMA4 P25789 REL Homo sapiens Q04864-2 32296183
Intra
PSMA4 P25789 REL Homo sapiens Q04864-2 32296183
Intra
PSMA4 P25789 REL Homo sapiens Q04864-2 32296183
Intra
PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
PSMA4 P25789 IKZF1 Homo sapiens Q13422-7 32296183
Intra
PSMA4 P25789 IKZF1 Homo sapiens Q13422-7 32296183
Intra
PSMA4 P25789 IKZF1 Homo sapiens Q13422-7 32296183
Intra
PSMA4 P25789 CARD9 Homo sapiens Q9H257-2 32296183
Intra
PSMA4 P25789 CARD9 Homo sapiens Q9H257-2 32296183
Intra
PSMA4 P25789 CARD9 Homo sapiens Q9H257-2 32296183
Intra
PSMA4 P25789 TRIM38 Homo sapiens O00635 32296183
Intra
PSMA4 P25789 PSMA3 Homo sapiens P25788
Y2H
14733938
Intra
PSMA4 P25789 PSMA3 Homo sapiens P25788 15225636
Intra
PSMA4 P25789 PSMA5 Homo sapiens P28066 35271311
Intra
PSMA4 P25789 PSMA1 Homo sapiens P25786 15225636
Intra
PSMA4 P25789 HTT Homo sapiens P42858 32814053
Intra
PSMA4 P25789 HTT Homo sapiens P42858 32814053
Intra
PSMA4 P25789 HTT Homo sapiens P42858 32814053
Intra
PSMA4 P25789 PSMA2 Homo sapiens P25787 35271311
Intra
PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
17948026
Intra
PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
14733938
Intra
PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
15225636
Intra
PSMA4 P25789 PSMA7 Homo sapiens O14818 15225636
Intra
PSMA4 P25789 PSMA7 Homo sapiens O14818 32296183
Intra
PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H
14733938
Intra
PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H
15225636
Intra
PSMA4 P25789 PSMA7 Homo sapiens O14818 32296183
Cross
PSMA4 P25789 Bhlhe41 Mus musculus Q99PV5 22801492
Intra
PSMA4 P25789 GOLGA2 Homo sapiens Q08379 25416956
Intra
PSMA4 P25789 GOLGA2 Homo sapiens Q08379 25416956
Intra
PSMA4 P25789 IKZF1 Homo sapiens Q13422 25416956
Intra
PSMA4 P25789 IKZF1 Homo sapiens Q13422 25416956
Intra
PSMA4 P25789 ATXN1 Homo sapiens P54253 32814053
Intra
PSMA4 P25789 ATXN1 Homo sapiens P54253 32814053
Intra
PSMA4 P25789 ATXN1 Homo sapiens P54253 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

PSMA4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82020 PSMA4 Antibody (YA1765) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82020A PSMA4 Antibody (YA1765)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Tobacco Addiction
  • Nicotine Dependence

  • Tobacco Addiction, Susceptibility To

  • Nicotine Addiction

  • Tobacco Use Disorder

  • Smoking Habit

  • Nicotine Dependence, Protection Against

  • Nicotine Addiction, Protection From

  • Cigarette Habituation

  • Cigarette Habituation, Susceptibility To

  • Smoking Habit, Susceptibility To

  • Nicotine Dependence, Susceptibility To

  • Nicotine Addiction, Susceptibility To

  • Addiction, Tobacco, Susceptibility To

  • Compulsive Tobacco User Syndrome

  • Tobacco Dependence

  • Tobacco Dependence Syndrome

  • Cigarette Addiction

  • Cigarette Dependence

  • Smoking Addiction

  • Smokers Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PSMA4 VGNC VGNC:76439
Mus musculus PSMA4 MGD MGI:1347060
Bos taurus PSMA4 VGNC VGNC:33439
Felis catus PSMA4 VGNC VGNC:80886
Rattus norvegicus PSMA4 RGD RGD:61846
Others PSMA4 NCBI