PSMA5 - proteasome 20S subunit alpha 5 Gene

Also Known as PSC5; ZETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5686

About PSMA5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,399,042-109,426,448 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 14.6), appendix (RPKM 13.2) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PSMA5 Products (4)

mRNA	Protein	Name
NM_001199772.2	NP_001186701.1	proteasome subunit alpha type-5 isoform 2
NM_001199773.2	NP_001186702.1	proteasome subunit alpha type-5 isoform 2
NM_001199774.2	NP_001186703.1	proteasome subunit alpha type-5 isoform 2
NM_002790.4	NP_002781.2	proteasome subunit alpha type-5 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15225636	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome core complex, alpha-subunit complex	IDA IDA: Inferred from direct assay	30133132	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMA5 Protein Structure

Proteasome_A_N

Proteasome

0
100
200
241 a.a.

Protein Preferred Names	Protein Names
proteasome subunit alpha type-5	epididymis tissue sperm binding protein Li 11n

PSMA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PSMA5	P28066	PSMA4	Homo sapiens	P25789	Pull Down	15225636
Intra	PSMA5	P28066	PSMA4	Homo sapiens	P25789	Anti Tag CoIP	33961781
Intra	PSMA5	P28066	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	33961781
Intra	PSMA5	P28066	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Renal Wilms' Tumor	Nonanaplastic Renal Wilm'S Tumor Nonanaplastic Renal Wilm'S Tumour Nonanaplastic Renal Wilms Tumor Renal Wilms' Tumour
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-D3189	5GluAF-2MeTG		/	Unkown
HY-P11485	JR11-PEG3-HBED-CC-PSMA-03		/	Unkown
HY-P11488	JR11-PEG3-DOTA-PSMA-03	Ligand	/	Unkown
HY-RS11295	PSMA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMA5	RGD	RGD:61848
Mus musculus	PSMA5	MGD	MGI:1347009
Canis familiaris	PSMA5	VGNC	VGNC:54060
Macaca mulatta	PSMA5	VGNC	VGNC:76440
Felis catus	PSMA5	VGNC	VGNC:80331
Bos taurus	PSMA5	VGNC	VGNC:33440
Others	PSMA5	NCBI