2. Antibody-drug Conjugate/ADC Related Neuronal Signaling GPCR/G Protein Immunology/Inflammation
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA
  4. JR11-PEG3-HBED-CC-PSMA-03

JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [68Ga]. [68Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer.

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JR11-PEG3-HBED-CC-PSMA-03

JR11-PEG3-HBED-CC-PSMA-03 Estructura química

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JR11-PEG3-HBED-CC-PSMA-03 Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Descripciòn

JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [68Ga]. [68Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer[1].

IC50 & Target[1]

SSTR2

 

Peso molecular

2701.38

Fòrmula

C127H163ClN24O36S2
Sequence

{Phe(p-Cl)}-cyclo({d-Cys}-Phe-{d-4-amino-Phe(carbamoyl)}-Lys-Thr-Cys){d-Tyr}-NH2-PEG3-HBED-CC-PSMA-03
Sequence Shortening

{Phe(p-Cl)}-cyclo({d-Cys}-F-{d-4-amino-Phe(carbamoyl)}-KTC){d-Tyr}-NH2-PEG3-HBED-CC-PSMA-03
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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JR11-PEG3-HBED-CC-PSMA-03 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JR11-PEG3-HBED-CC-PSMA-03Radionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorPSMASSTRsSSTRProstate-specific membrane antigenprostate cancerInhibitorinhibitorinhibit

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Nombre del producto:
JR11-PEG3-HBED-CC-PSMA-03
Cat. No.:
HY-P11485
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