5GluAF-2MeTG
5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens.
For research use only. We do not sell to patients.
- CAS No.: 2370825-44-6
- Formula: C26H21N3O8
- Molecular Weight:503.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5GluAF-2MeTG (10 μM; 10 hr at 37 °C) undergoes robust, time-dependent fluorescence activation in PSMA-positive LNCaP cell lysate, with no activation in PSMA-negative PC3 cell lysate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2370825-44-6
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Molecular Weight 503.46
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Formula C26H21N3O8
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SMILES
CC1=CC=C(/N=N/C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C1C(C2=CC=C(O)C=C2O3)=C(C=C4)C3=CC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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