2. Others Immunology/Inflammation
  3. Fluorescent Dye PSMA
  4. 5GluAF-2MeTG

5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens.

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5GluAF-2MeTG

5GluAF-2MeTG Chemical Structure

CAS No. : 2370825-44-6

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5GluAF-2MeTG Related Antibodies

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Description

5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens[1].

In Vitro

5GluAF-2MeTG (10 μM; 10 hr at 37 °C) undergoes robust, time-dependent fluorescence activation in PSMA-positive LNCaP cell lysate, with no activation in PSMA-negative PC3 cell lysate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5GluAF-2MeTG Related Antibodies
Molecular Weight

503.46

Formula

C26H21N3O8
CAS No.
SMILES

CC1=CC=C(/N=N/C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C1C(C2=CC=C(O)C=C2O3)=C(C=C4)C3=CC4=O
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Room temperature in continental US; may vary elsewhere.
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References
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5GluAF-2MeTG Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5GluAF-2MeTG2370825-44-6Fluorescent DyePSMAProstate-specific membrane antigenprostate cancer cellsdonor-excited photo-induced electron transferLNCaP cell lysaterecombinant human PSMAPC3 cell lysatePC3 cellscarboxypeptidase activityLNCaP living cellsprostate cancerInhibitorinhibitorinhibit

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