2370825-44-6
Chemical Structure
5GluAF-2MeTG
- CAS No.: 2370825-44-6
- Formula:C26H21N3O8
- Molecular Weight:503.46
InChIKey: YPNXIZXOLXHHJP-SHKWJFPUSA-N
SMILES: CC1=CC=C(/N=N/C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C1C(C2=CC=C(O)C=C2O3)=C(C=C4)C3=CC4=O
Biological Activity: 5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens[1].
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5GluAF-2MeTG | 5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens. | |||||||||||||||||||||
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