PSMF1 - proteasome inhibitor subunit 1 Gene

Also Known as PI31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9491

About PSMF1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,113,263-1,172,246 (from NCBI)

This gene has 11 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 17.3), ovary (RPKM 9.5) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the Proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PSMF1 Products (6)

mRNA	Protein	Name
NM_001323407.2	NP_001310336.1	proteasome inhibitor PI31 subunit isoform 3
NM_001323408.2	NP_001310337.1	proteasome inhibitor PI31 subunit isoform 4
NM_001323409.2	NP_001310338.1	proteasome inhibitor PI31 subunit isoform 5
NM_001323410.2	NP_001310339.1	proteasome inhibitor PI31 subunit isoform 6
NM_006814.5	NP_006805.2	proteasome inhibitor PI31 subunit isoform 1
NM_178578.4	NP_848693.2	proteasome inhibitor PI31 subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables proteasome binding	IDA IDA: Inferred from direct assay	10764772	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16000308	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	18495667	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18495667	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	10764772	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10764772	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	18495667	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18495667	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18495667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMF1 Protein Structure

PI31_Prot_N

PI31_Prot_C

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
proteasome inhibitor PI31 subunit	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

PSMF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMF1	Q92530	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	PSMF1	Q92530	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	PSMF1	Q92530	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	PSMF1	Q92530	FBXO7	Homo sapiens	Q9Y3I1	Y2H Prey Pooling	25416956
Intra	PSMF1	Q92530	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311
Intra	PSMF1	Q92530	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	33961781
Intra	PSMF1	Q92530	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	PSMF1	Q92530	LDOC1	Homo sapiens	O95751	Y2H Pooling	19060904
Intra	PSMF1	Q92530	LDOC1	Homo sapiens	O95751	Y2H Array	19060904
Intra	PSMF1	Q92530	PAK5	Homo sapiens	Q9P286	Y2H Array	19060904
Intra	PSMF1	Q92530	PAK5	Homo sapiens	Q9P286	Y2H Array	31515488
Intra	PSMF1	Q92530	PAK5	Homo sapiens	Q9P286	Y2H Pooling	19060904
Intra	PSMF1	Q92530	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	PSMF1	Q92530	CD2BP2	Homo sapiens	O95400	Y2H	16000308
Intra	PSMF1	Q92530	CD2BP2	Homo sapiens	O95400	Protein Array	16000308
Intra	PSMF1	Q92530	RBFOX1	Homo sapiens	Q9NWB1	Y2H Array	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11335	PSMF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMF1	VGNC	VGNC:76458
Rattus norvegicus	PSMF1	RGD	RGD:1587528
Canis familiaris	PSMF1	VGNC	VGNC:45120
Felis catus	PSMF1	VGNC	VGNC:69129
Mus musculus	PSMF1	MGD	MGI:1346072
Bos taurus	PSMF1	VGNC	VGNC:33477
Others	PSMF1	NCBI