PSMF1 - proteasome inhibitor subunit 1 Gene

Homo sapiens

Also known as PI31

Gene ID: 9491 | Gene type: protein coding

About PSMF1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,113,263-1,172,246 (from NCBI)

This gene has 11 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 17.3), ovary (RPKM 9.5) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a protein that inhibits the activation of the Proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PSMF1 Products(6)

mRNA	Protein	Name
NM_001323407.2	NP_001310336.1	proteasome inhibitor PI31 subunit isoform 3
NM_001323408.2	NP_001310337.1	proteasome inhibitor PI31 subunit isoform 4
NM_001323409.2	NP_001310338.1	proteasome inhibitor PI31 subunit isoform 5
NM_001323410.2	NP_001310339.1	proteasome inhibitor PI31 subunit isoform 6
NM_006814.5	NP_006805.2	proteasome inhibitor PI31 subunit isoform 1
NM_178578.4	NP_848693.2	proteasome inhibitor PI31 subunit isoform 1

PSMF1 Protein Structure

PI31_Prot_N

PI31_Prot_C

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

proteasome inhibitor PI31 subunit

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Related Diseases

Diseases

Alias

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11335	PSMF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMF1	VGNC	VGNC:76458
Rattus norvegicus	PSMF1	RGD	RGD:1587528
Canis familiaris	PSMF1	VGNC	VGNC:45120
Felis catus	PSMF1	VGNC	VGNC:69129
Mus musculus	PSMF1	MGD	MGI:1346072
Bos taurus	PSMF1	VGNC	VGNC:33477

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