FBXO7 - F-box protein 7 Gene

Also Known as FBX; FBX7; PKPS; FBX07; PARK15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25793

About FBXO7

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,474,811-32,498,829 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 94.0), thyroid (RPKM 68.7) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

FBXO7 Products (3)

mRNA	Protein	Name
NM_001033024.2	NP_001028196.1	F-box only protein 7 isoform 2
NM_001257990.2	NP_001244919.1	F-box only protein 7 isoform 3
NM_012179.4	NP_036311.3	F-box only protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15145941	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	18495667	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18495667	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	25029497	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16510124	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	15145941	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	23933751	GOA
acts upstream of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	26310625	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	25029497	GOA
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	26310625	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	36646384	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36646384	GOA
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	23933751	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16510124	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	23933751	GOA
involved in regulation of locomotion	IDA IDA: Inferred from direct assay	26310625	GOA
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	25029497	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	15145941	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25029497	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Lewy body core	IDA IDA: Inferred from direct assay	23656991	GOA
located in Lewy body corona	IDA IDA: Inferred from direct assay	23656991	GOA
located in Lewy neurite	IDA IDA: Inferred from direct assay	23656991	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15145941	GOA
located in classical Lewy body	IDA IDA: Inferred from direct assay	23656991	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16510124	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18495667	GOA
located in glial cytoplasmic inclusion	IDA IDA: Inferred from direct assay	23656991	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23933751	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	36646384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16510124	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	23933751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO7 Protein Structure

PI31_Prot_N

F-box-like

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
F-box only protein 7

FBXO7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	FBXO7	Q9Y3I1	PINK1	Homo sapiens	Q9BXM7	Pull Down	23933751
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	28514442
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	16278047
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	26496610
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Validated Y2H	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Bait-Prey Pool	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Array	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FBXO7	Q9Y3I1	PSME3	Homo sapiens	P61289	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	PRKN	Homo sapiens	O60260	Pull Down	23933751
Intra	FBXO7	Q9Y3I1	PRKN	Homo sapiens	O60260	Anti Tag CoIP	23933751
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Validated Y2H	25910212
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Bait-Prey Pool	25910212
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Validated Y2H	25416956
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	33961781
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	31515488
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	26496610
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	28514442
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Early-Onset Parkinson'S Disease	Early-Onset Parkinson Disease
Kufor-Rakeb Syndrome	Park9 Krppd KRS Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia Autosomal Recessive Parkinson Disease 9 Parkinson Disease 9 Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset Autosomal Recessive Juvenile Onset Parkinson Disease 9 Parkinson Disease Type 9 Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia Park 9 Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis Cln12 Disease Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis Parkinson Disease Autosomal Recessive 9
Parkinson Disease 3, Autosomal Dominant	PARK3 Parkinson Disease 3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Pyromania	Firesetting Behavior Pathological Firesetting Pathological Fire-Setting
Vertebrobasilar Insufficiency	Vertebro-Basilar Insufficiency Vertebrobasilar Arterial Insufficiency Vertebrobasilar Artery Syndrome
Meier-Gorlin Syndrome 3	MGORS3 Meier-Gorlin Syndrome, Type 3
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Neurodegeneration With Brain Iron Accumulation 2b	NBIA2B Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related Neuroaxonal Dystrophy, Atypical Karak Syndrome Atypical Neuroaxonal Dystrophy Neurodegeneration With Brain Iron Accumulation Pla2g6-Related Neurodegeneration, With Brain Iron Accumulation, Type 2b Neurodegeneration With Brain Iron Accumulation 2
Perry Syndrome	Parkinsonism With Alveolar Hypoventilation And Mental Depression PERRYS
Vascular Parkinsonism
Neuroaxonal Dystrophy	Neuroaxonal Dystrophies
Movement Disease	Movement Disorders Movement Disorder
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162240	SJH1-51B	Degrader	/	Unkown
HY-RS04813	FBXO7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22503	Fbxo7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29025	Fbxo7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FBXO7	VGNC	VGNC:40789
Macaca mulatta	FBXO7	VGNC	VGNC:72491
Bos taurus	FBXO7	VGNC	VGNC:28919
Felis catus	FBXO7	VGNC	VGNC:62198
Rattus norvegicus	FBXO7	RGD	RGD:1305648
Mus musculus	FBXO7	MGD	MGI:1917004
Others	FBXO7	NCBI