TENT5B - terminal nucleotidyltransferase 5B Gene

Also Known as FAM46; FAM46B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115572

Summary

Enables poly(A) RNA polymerase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of translation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Biased expression in esophagus (RPKM 30.7), skin (RPKM 15.3) and 11 other tissues.

TENT5B Products (1)

mRNA Protein Name
NM_052943.4 NP_443175.2 terminal nucleotidyltransferase 5B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables poly(A) RNA polymerase activity IDA
IDA: Inferred from direct assay
32009146 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
32009146 GOA
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
30532005 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
30532005 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
32009146 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
32009146 GOA
located in nucleus IDA
IDA: Inferred from direct assay
32009146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENT5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TENT5B Q96A09 RIMBP3 Homo sapiens Q9UFD9
Validated Y2H
32296183
Intra
TENT5B Q96A09 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
32296183
Intra
TENT5B Q96A09 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 NR1D2 Homo sapiens Q6NSM0
Y2H Array
32296183
Intra
TENT5B Q96A09 NR1D2 Homo sapiens Q6NSM0
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
TENT5B Q96A09 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
TENT5B Q96A09 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
TENT5B Q96A09 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
TENT5B Q96A09 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
TENT5B Q96A09 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra
TENT5B Q96A09 AKAP9 Homo sapiens Q6PJH3
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
TENT5B Q96A09 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
TENT5B Q96A09 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
TENT5B Q96A09 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
TENT5B Q96A09 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
TENT5B Q96A09 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
TENT5B Q96A09 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
TENT5B Q96A09 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Intra
TENT5B Q96A09 FOXI1 Homo sapiens Q12951-2
Y2H Array
32296183
Intra
TENT5B Q96A09 FOXI1 Homo sapiens Q12951-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
TENT5B Q96A09 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
TENT5B Q96A09 CIMIP2B Homo sapiens A8MTA8-2
Y2H Array
32296183
Intra
TENT5B Q96A09 CIMIP2B Homo sapiens A8MTA8-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
TENT5B Q96A09 CERCAM Homo sapiens Q5T4B2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 CERCAM Homo sapiens Q5T4B2
Y2H Array
32296183
Intra
TENT5B Q96A09 SOHLH1 Homo sapiens Q5JUK2
Y2H Array
32296183
Intra
TENT5B Q96A09 SOHLH1 Homo sapiens Q5JUK2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
TENT5B Q96A09 SLC15A2 Homo sapiens Q16348
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 SLC15A2 Homo sapiens Q16348
Y2H Array
32296183
Intra
TENT5B Q96A09 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
TENT5B Q96A09 SLC27A4 Homo sapiens Q6P1M0-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 SLC27A4 Homo sapiens Q6P1M0-2
Y2H Array
32296183
Intra
TENT5B Q96A09 NICN1 Homo sapiens Q9BSH3
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 NICN1 Homo sapiens Q9BSH3
Validated Y2H
32296183
Intra
TENT5B Q96A09 NICN1 Homo sapiens Q9BSH3
Y2H Array
32296183
Intra
TENT5B Q96A09 C3orf36 Homo sapiens Q3SXR2
Y2H Array
32296183
Intra
TENT5B Q96A09 C3orf36 Homo sapiens Q3SXR2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
TENT5B Q96A09 NAF1 Homo sapiens Q96HR8
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 NAF1 Homo sapiens Q96HR8
Validated Y2H
32296183
Intra
TENT5B Q96A09 NAF1 Homo sapiens Q96HR8
Y2H Array
32296183
Intra
TENT5B Q96A09 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
Intra
TENT5B Q96A09 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
TENT5B Q96A09 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
TENT5B Q96A09 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
TENT5B Q96A09 FOSB Homo sapiens P53539
Y2H Array
32296183
Intra
TENT5B Q96A09 FOSB Homo sapiens P53539
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 TBX6 Homo sapiens O95947
Y2H Array
32296183
Intra
TENT5B Q96A09 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
TENT5B Q96A09 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
TENT5B Q96A09 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
TENT5B Q96A09 SOX5 Homo sapiens P35711
Y2H Prey Pooling
25416956
Intra
TENT5B Q96A09 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
TENT5B Q96A09 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
TENT5B Q96A09 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
TENT5B Q96A09 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
TENT5B Q96A09 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
TENT5B Q96A09 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
TENT5B Q96A09 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
TENT5B Q96A09 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
TENT5B Q96A09 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
TENT5B Q96A09 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
TENT5B Q96A09 PSMB8 Homo sapiens P28062-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 PSMB8 Homo sapiens P28062-2
Y2H Array
32296183
Intra
TENT5B Q96A09 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
TENT5B Q96A09 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
TENT5B Q96A09 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
TENT5B Q96A09 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
TENT5B Q96A09 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
TENT5B Q96A09 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
TENT5B Q96A09 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 SH2D2A Homo sapiens Q9NP31
Lumier
25814554
Intra
TENT5B Q96A09 SH2D2A Homo sapiens Q9NP31
Validated Y2H
25814554
Intra
TENT5B Q96A09 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
TENT5B Q96A09 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
TENT5B Q96A09 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
TENT5B Q96A09 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
TENT5B Q96A09 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
TENT5B Q96A09 DAZAP2 Homo sapiens Q15038
Y2H Pooling
19060904
Intra
TENT5B Q96A09 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
TENT5B Q96A09 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 DAZAP2 Homo sapiens Q15038
Y2H Array
19060904
Intra
TENT5B Q96A09 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
Intra
TENT5B Q96A09 HMGXB4 Homo sapiens Q9UGU5
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 HMGXB4 Homo sapiens Q9UGU5
Y2H Array
32296183
Intra
TENT5B Q96A09 ACY1 Homo sapiens Q03154
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ACY1 Homo sapiens Q03154
Y2H Array
32296183
Intra
TENT5B Q96A09 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
TENT5B Q96A09 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
TENT5B Q96A09 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 RFX6 Homo sapiens Q8HWS3
Y2H Array
32296183
Intra
TENT5B Q96A09 PLK4 Homo sapiens O00444
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 PLK4 Homo sapiens O00444
Y2H Array
32296183
Intra
TENT5B Q96A09 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
TENT5B Q96A09 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
TENT5B Q96A09 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
TENT5B Q96A09 FOS Homo sapiens P01100
Y2H Array
32296183
Intra
TENT5B Q96A09 FOS Homo sapiens P01100
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ZNF503 Homo sapiens Q96F45
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ZNF503 Homo sapiens Q96F45
Validated Y2H
32296183
Intra
TENT5B Q96A09 ZNF503 Homo sapiens Q96F45
Y2H Array
32296183
Intra
TENT5B Q96A09 PROP1 Homo sapiens O75360
Y2H Array
32296183
Intra
TENT5B Q96A09 PROP1 Homo sapiens O75360
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
TENT5B Q96A09 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 ATXN1 Homo sapiens P54253
Y2H Array
32296183
Intra
TENT5B Q96A09 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Intra
TENT5B Q96A09 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
TENT5B Q96A09 PSMF1 Homo sapiens Q92530
Y2H Array
32296183
Intra
TENT5B Q96A09 PSMF1 Homo sapiens Q92530
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
TENT5B Q96A09 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
TENT5B Q96A09 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
TENT5B Q96A09 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
TENT5B Q96A09 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14367 TENT5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14368 TENT5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown