HMGXB4 - HMG-box containing 4 Gene

Also Known as P53N; HMG2L1; HMGBCG; THC211630

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10042

About HMGXB4

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,241,536-35,295,807 (from NCBI)

This gene has 8 transcripts (splice variants), 230 orthologues and 20 paralogues. Ubiquitous expression in testis (RPKM 8.3), bone marrow (RPKM 7.9) and 25 other tissues.

Summary

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

HMGXB4 Products (2)

mRNA Protein Name
NM_001003681.3 NP_001003681.1 HMG domain-containing protein 4 isoform 1
NM_001362972.2 NP_001349901.1 HMG domain-containing protein 4 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
part of NURF complex IDA
IDA: Inferred from direct assay
20850016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGXB4 Protein Structure

DUF4171

DUF4171: Domain of unknown function (DUF4171) (107 - 233)

HMG_box

HMG_box: HMG (high mobility group) box (408 - 470)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 601 a.a.
Protein Preferred Names Protein Names

HMG domain-containing protein 4

  • HMG box domain containing 4

HMGXB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HMGXB4 Q9UGU5 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
HMGXB4 Q9UGU5 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
HMGXB4 Q9UGU5 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
HMGXB4 Q9UGU5 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
HMGXB4 Q9UGU5 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
Intra
HMGXB4 Q9UGU5 HMGXB4 Homo sapiens Q9UGU5
Y2H Array
32296183
Intra
HMGXB4 Q9UGU5 TSPYL2 Homo sapiens Q9H2G4
Y2H Array
32296183
Intra
HMGXB4 Q9UGU5 HMGXB4 Homo sapiens Q9UGU5
Y2H Prey Pooling
32296183
Intra
HMGXB4 Q9UGU5 TSPYL2 Homo sapiens Q9H2G4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06247 HMGXB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HMGXB4 VGNC VGNC:73482
Mus musculus HMGXB4 MGD MGI:1918073
Canis familiaris HMGXB4 VGNC VGNC:41717
Felis catus HMGXB4 VGNC VGNC:67594
Bos taurus HMGXB4 VGNC VGNC:29883
Rattus norvegicus HMGXB4 RGD RGD:1305783
Others HMGXB4 NCBI