FOSB - FosB proto-oncogene, AP-1 transcription factor subunit Gene

Homo sapiens

Also known as AP-1; G0S3; GOS3; GOSB

Gene ID: 2354 | Gene type: protein coding

About FOSB

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,467,996-45,475,179 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 8 paralogues. Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues.

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FOSB Products(3)

mRNA	Protein	Name
NM_001114171.2	NP_001107643.1	protein FosB isoform 2
NM_001411069.1	NP_001397998.1	protein FosB isoform 3
NM_006732.3	NP_006723.2	protein FosB isoform 1

FOSB Protein Structure

bZIP_1

0
100
200
300
338 a.a.

Protein Preferred Names

Protein Names

protein FosB

FBJ murine osteosarcoma viral oncogene homolog B

Related Diseases

Diseases

Alias

Osteoblastoma

Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia	Epithelioid Haemangioma
Epithelioid Hemangioma

Proliferative Fasciitis

Hemangioendothelioma

Malignant Epithelioid Hemangioendothelioma

Epithelioid Hemangioendothelioma, Malignant

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Subdural Empyema

Empyema, Subdural

Subdural Abscess

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Hobnail Hemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N12361	Osmanthuside B	Inhibitor	98.40%	Unkown
HY-RS05033	FOSB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOSB	VGNC	VGNC:62330
Canis familiaris	FOSB	VGNC	VGNC:40941
Bos taurus	FOSB	VGNC	VGNC:29074
Mus musculus	FOSB	MGD	MGI:95575
Rattus norvegicus	FOSB	RGD	RGD:1308198

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