FOSB - FosB proto-oncogene, AP-1 transcription factor subunit Gene

Also Known as AP-1; G0S3; GOS3; GOSB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2354

About FOSB

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,467,996-45,475,179 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 8 paralogues. Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues.

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FOSB Products (3)

mRNA Protein Name
NM_001114171.2 NP_001107643.1 protein FosB isoform 2
NM_001411069.1 NP_001397998.1 protein FosB isoform 3
NM_006732.3 NP_006723.2 protein FosB isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22387553 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOSB Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (153 - 211)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
Protein Preferred Names Protein Names

protein FosB

  • FBJ murine osteosarcoma viral oncogene homolog B

FOSB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOSB P53539 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
FOSB P53539 CYTH4 Homo sapiens Q9UIA0
Validated Y2H
32296183
Intra
FOSB P53539 ATF2 Homo sapiens P15336
Anti Tag CoIP
33961781
Intra
FOSB P53539 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
FOSB P53539 NEDD9 Homo sapiens Q14511-2
Validated Y2H
32296183
Intra
FOSB P53539 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra
FOSB P53539 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
FOSB P53539 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
Intra
FOSB P53539 ROR2 Homo sapiens Q01974
Validated Y2H
32296183
Intra
FOSB P53539 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
FOSB P53539 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
Intra
FOSB P53539 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Intra
FOSB P53539 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
FOSB P53539 CENPO Homo sapiens Q9BU64
Validated Y2H
32296183
Intra
FOSB P53539 JUNB Homo sapiens P17275
Anti Tag CoIP
33961781
Intra
FOSB P53539 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
FOSB P53539 FOXP3 Homo sapiens Q9BZS1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

FOSB Antibodies

Cat. No. Product Name Application Reactivity
HY-P80131 Fos B Antibody (YA431) WB, IHC-P, IP Human, Mouse
HY-P81753 Fos B Antibody (YA1498) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Osteoblastoma
Histiocytoid Hemangioma

  • Angiolymphoid Hyperplasia With Eosinophilia

  • Epithelioid Haemangioma

  • Epithelioid Hemangioma
Proliferative Fasciitis
Hemangioendothelioma
Malignant Epithelioid Hemangioendothelioma

  • Epithelioid Hemangioendothelioma, Malignant
Spindle Cell Hemangioma

  • Sch

  • Spindle Cell Hemangioendothelioma
Endosteal Hyperostosis, Autosomal Dominant

  • Osteosclerosis

  • Worth Syndrome

  • Osteosclerosis, Autosomal Dominant

  • Hyperostosis, Endosteal

  • Endosteal Hyperostosis, Worth Type

  • Worth Disease

  • Autosomal Dominant Endosteal Hyperostosis

  • Autosomal Dominant Osteosclerosis, Worth Type

  • Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus

  • Autosomal Dominant Osteosclerosis

  • Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus

  • Worth'S Syndrome

  • Worth Type Autosomal Dominant Osteosclerosis

  • Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus

  • Osteosclerosis, Autosomal Dominant, Worth Type

  • WENHY

  • Endosteal Hyperostosis Autosomal Dominant

  • Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus

  • Osteosclerosis Autosomal Dominant

  • Acquired Osteosclerosis
Subdural Empyema

  • Empyema, Subdural

  • Subdural Abscess
Intracranial Berry Aneurysm

  • Familial Aneurysmal Subarachnoid Hemorrhage

  • Familial Berry Aneurysm

  • Familial Intracranial Saccular Aneurysm

  • Saccular Cerebral Aneurysm

  • Aneurysm, Intracranial Berry

  • Aneurysmal Subarachnoid Hemorrhage

  • Aneurysm, Intracranial Berry, 1
Hobnail Hemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179594 HTS10307 Inhibitor / Unkown
HY-W471288 JPC0661 Inhibitor / Unkown
HY-170916 Angiogenesis inhibitor 7 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FOSB VGNC VGNC:62330
Canis familiaris FOSB VGNC VGNC:40941
Bos taurus FOSB VGNC VGNC:29074
Mus musculus FOSB MGD MGI:95575
Rattus norvegicus FOSB RGD RGD:1308198
Others FOSB NCBI