GLIS2 - GLIS family zinc finger 2 Gene

Also Known as NKL; NPHP7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84662

About GLIS2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,314,761-4,339,595 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 253 orthologues, 14 paralogues and is associated with 4 phenotypes. Broad expression in kidney (RPKM 14.7), lung (RPKM 9.3) and 23 other tissues.

Summary

This gene is a member of the GLI-similar Zinc Finger Protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]

GLIS2 Products (2)

mRNA	Protein	Name
NM_001318918.2	NP_001305847.1	zinc finger protein GLIS2
NM_032575.3	NP_115964.2	zinc finger protein GLIS2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17289029	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLIS2 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
zinc finger protein GLIS2	GLI-similar 2

GLIS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GLIS2	Q9BZE0	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	GPSM1	Homo sapiens	Q86YR5-3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	GPSM1	Homo sapiens	Q86YR5-3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	AKAP9	Homo sapiens	Q6PJH3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	AKAP9	Homo sapiens	Q6PJH3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-3	Homo sapiens	Q7Z4W3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	KRTAP19-3	Homo sapiens	Q7Z4W3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	GLIS2	Q9BZE0	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	SHOX	Homo sapiens	O15266-2	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	SHOX	Homo sapiens	O15266-2	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	PLEKHB1	Homo sapiens	Q9UF11-2	Validated Y2H	32296183
Intra	GLIS2	Q9BZE0	PLEKHB1	Homo sapiens	Q9UF11-2	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	PLEKHB1	Homo sapiens	Q9UF11-2	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CREM	Homo sapiens	Q03060-25	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CREM	Homo sapiens	Q03060-25	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	TWIST2	Homo sapiens	Q8WVJ9	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	FOSB	Homo sapiens	P53539	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CSNK2B	Homo sapiens	P67870	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CSNK2B	Homo sapiens	P67870	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	VBP1	Homo sapiens	P61758	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	VBP1	Homo sapiens	P61758	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	GMNN	Homo sapiens	O75496	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	GMNN	Homo sapiens	O75496	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	CTNNB1	Homo sapiens	P35222	Y2H Pooling	17289029
Intra	GLIS2	Q9BZE0	CTNNB1	Homo sapiens	P35222	Pull Down	17289029
Intra	GLIS2	Q9BZE0	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	GLIS2	Q9BZE0	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	BCAR1	Homo sapiens	P56945	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	BCAR1	Homo sapiens	P56945	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	RBPMS	Homo sapiens	Q93062-3	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	RBPMS	Homo sapiens	Q93062-3	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	RBM11	Homo sapiens	P57052	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	GLIS2	Q9BZE0	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	GLIS2	Q9BZE0	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	GLIS2	Q9BZE0	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephronophthisis 7	NPHP7 Nephronophthisis, Type 7
Acute Megakaryoblastic Leukemia Without Down Syndrome	Non-Ds-Amkl
Juvenile Nephronophthisis	Nephronophthisis Nephronophthisis, Familial Juvenile
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Childhood Acute Megakaryoblastic Leukemia	Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Myeloid Leukemia Associated With Down Syndrome
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Nephronophthisis 15	NPHP15 Nephronophthisis, Type 15
Nephronophthisis 20	NPHP20
Cd3zeta Deficiency
Nephronophthisis 19	NPHP19 Nephronophthisis, Type 19
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Aggressive Nk-Cell Leukemia	Aggressive Nk-Cell Leukaemia Large Granular Lymphocyte Leukemia, Nk-Cell Type Natural Killer Cell Leukaemia Natural Killer Cell Leukemia Aggressive Nk Cell Leukemia Ankl Aggressive Natural Killer Cell Leukemia Ankcl Aggressive Nk-Cell Lymphoma Nk-Cell Lgl Leukemia Nk-Cell Large Granular Lymphocyte Leukemia Abnormality Of The Ankles Aggressive Natural Killer-Cell Leukemia Leukemia, Large Granular Lymphocytic Leukemia, Natural Killer Cell Large Granular Lymphocytic
Nephronophthisis 2	NPHP2 Nph2 Nephronophthisis 2, Infantile Infantile Nephronophthisis 2 Infantile Nephronophthisis Nephronophthisis, Type 2
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Hypertrichosis Universalis Congenita, Ambras Type	Ambras Syndrome Hypertrichosis, Congenital Generalized HTC1 HTC2 Chromosome Xq27.1 Interchromosomal Insertion Syndrome Cgh Hcg Ambras Type Hypertrichosis Universalis Congenita X-Linked Congenital Generalized Hypertrichosis Congenital Generalized Hypertrichosis, Macias-Flores Type Macias Flores-Garcia Cruz-Rivera Syndrome Htc 1 Hypertrichosis Universalis Congenita Ambras Type Hypertrichosis Congenital Generalized X-Linked Macias-Flores Garcia-Cruz Rivera Syndrome Congenital Generalized Hypertrichosis, Ambras Type
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Senior-Loken Syndrome 1	Senior-Loken Syndrome Renal Dysplasia And Retinal Aplasia Renal-Retinal Syndrome Loken-Senior Syndrome Juvenile Nephronophthisis With Leber Amaurosis SLSN1 Senior-Loken Syndrome-1 Loken Senior Syndrome Senior Loken Syndrome Renal Dysplasia Retinal Aplasia Nephronophthisis With Retinal Dystrophy Renal Dysplasia-Retinal Aplasia Syndrome Slsn
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13901	GANT 61		99.80%	Unkown
HY-RS05475	GLI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-137567	Prostaglandin E1 ethanolamide	Activator	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-RS05481	GLIS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20743	Gli2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21582	Glis2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27255	Gli2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28100	Glis2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLIS2	RGD	RGD:1309177
Felis catus	GLIS2	VGNC	VGNC:62581
Bos taurus	GLIS2	VGNC	VGNC:29407
Canis familiaris	GLIS2	VGNC	VGNC:41262
Macaca mulatta	GLIS2	VGNC	VGNC:73031
Mus musculus	GLIS2	MGD	MGI:1932535
Others	GLIS2	NCBI