GMNN - geminin DNA replication inhibitor Gene

Also Known as Gem; MGORS6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51053

About GMNN

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,774,937-24,786,099 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

GMNN Products (4)

mRNA	Protein	Name
NM_001251989.2	NP_001238918.1	geminin
NM_001251990.2	NP_001238919.1	geminin
NM_001251991.1	NP_001238920.1	geminin
NM_015895.5	NP_056979.1	geminin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16924111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11125146	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication preinitiation complex assembly	IDA IDA: Inferred from direct assay	11125146	GOA
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	9635433	GOA
involved in negative regulation of DNA-templated DNA replication	IDA IDA: Inferred from direct assay	11125146	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16924111	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	9635433	GOA
involved in positive regulation of chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	17234884	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: Inferred from direct assay	24064211	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	21543332	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21543332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21543332	GOA
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	22615398	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMNN Protein Structure

Geminin

0
100
209 a.a.

Protein Preferred Names	Protein Names
geminin

GMNN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GMNN	O75496	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Prey Pooling	25416956
Intra	GMNN	O75496	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	GMNN	O75496	PTPN11	Homo sapiens	Q06124-2	Validated Y2H	32296183
Intra	GMNN	O75496	HOXC9	Homo sapiens	P31274	ITC	22615398
Intra	GMNN	O75496	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	GMNN	O75496	SAPCD2	Homo sapiens	Q86UD0	Validated Y2H	32296183
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Bait CoIP	21543332
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	33961781
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	IF	21543332
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	28514442
Intra	GMNN	O75496	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	21543332
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	CoIP	11125146
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	17318181
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Pull Down	14993212
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	FRET	17318181
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	26496610
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Validated Y2H	27107012
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	SPR	21543332
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	33961781
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Anti Tag CoIP	28514442
Intra	GMNN	O75496	CDT1	Homo sapiens	Q9H211	Protein Array	15232106
Intra	GMNN	O75496	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	GMNN	O75496	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Y2H Prey Pooling	25416956
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Validated Y2H	32296183
Intra	GMNN	O75496	ZNF439	Homo sapiens	Q8NDP4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

GMNN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81394	Geminin Antibody (YA1139)	IHC-P	Human
HY-P81394A	Geminin Antibody (YA1139)(PBS only)	IHC-P	Human
HY-P83863	Geminin Antibody (YA3560)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83863A	Geminin Antibody (YA3560)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83864	Geminin Antibody (YA3561)	IHC-P, FC, ELISA	Human, Rat
HY-P83864A	Geminin Antibody (YA3561)(PBS only)	IHC-P, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 6	MGORS6
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Melanoacanthoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05523	GMNN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180858	GMNN modulator-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GMNN	VGNC	VGNC:41291
Bos taurus	GMNN	VGNC	VGNC:29439
Rattus norvegicus	GMNN	RGD	RGD:1308137
Mus musculus	GMNN	MGD	MGI:1927344
Felis catus	GMNN	VGNC	VGNC:62609
Macaca mulatta	GMNN	VGNC	VGNC:72954
Others	GMNN	NCBI