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HOXC9 - homeobox C9 Gene

Also Known as HOX3; HOX3B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3225

About HOXC9

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,000,161-54,003,337 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 42 paralogues. Biased expression in kidney (RPKM 2.8), fat (RPKM 2.6) and 10 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]

HOXC9 Products (1)

mRNA	Protein	Name
NM_006897.3	NP_008828.1	homeobox protein Hox-C9

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18305892	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	22615398	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC9 Protein Structure

Hox9_act

Homeobox

0
100
200
260 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-C9	homeo box C9

HOXC9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	HOXC9	P31274	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	HOXC9	P31274	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	HOXC9	P31274	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	HOXC9	P31274	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	HOXC9	P31274	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	HOXC9	P31274	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	HOXC9	P31274	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	HOXC9	P31274	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	HOXC9	P31274	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	HOXC9	P31274	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Cross	HOXC9	P31274	E2	Human papillomavirus	P03120	Y2H	18305892
Cross	HOXC9	P31274	E2	Human papillomavirus	P03120	SLC	22761572
Intra	HOXC9	P31274	PAX8	Homo sapiens	Q06710	Validated Y2H	32296183
Intra	HOXC9	P31274	PAX8	Homo sapiens	Q06710	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	PAX8	Homo sapiens	Q06710	Y2H Array	32296183
Intra	HOXC9	P31274	PBX2	Homo sapiens	P40425	Validated Y2H	32296183
Intra	HOXC9	P31274	PBX2	Homo sapiens	P40425	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	PBX2	Homo sapiens	P40425	Y2H Array	32296183
Intra	HOXC9	P31274	GMNN	Homo sapiens	O75496	Pull Down	22615398
Intra	HOXC9	P31274	GMNN	Homo sapiens	O75496	NMR	22615398
Intra	HOXC9	P31274	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HOXC9	P31274	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	MSX2	Homo sapiens	P35548	Validated Y2H	32296183
Intra	HOXC9	P31274	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	HOXC9	P31274	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	HOXC9	P31274	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	HOXC9	P31274	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	HOXC9	P31274	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	HOXC9	P31274	LPXN	Homo sapiens	O60711	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	LPXN	Homo sapiens	O60711	Y2H Array	32296183
Intra	HOXC9	P31274	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	HOXC9	P31274	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	HOXC9	P31274	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	HOXC9	P31274	POU2AF1	Homo sapiens	Q16633	Validated Y2H	32296183
Intra	HOXC9	P31274	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Distal Muscular Dystrophy With Anterior Tibial Onset	Dmat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-129108	9-cis-UAB30		/	Unkown
HY-RS06321	HOXC9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HOXC9	VGNC	VGNC:67630
Rattus norvegicus	HOXC9	RGD	RGD:1595784
Bos taurus	HOXC9	VGNC	VGNC:29928
Mus musculus	HOXC9	MGD	MGI:96199
Others	HOXC9	NCBI