PBX2 - PBX homeobox 2 Gene

Homo sapiens

Also known as G17; HOX12; PBX2MHC

Gene ID: 5089 | Gene type: protein coding

About PBX2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,184,733-32,190,202 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 132 orthologues and 12 paralogues. Ubiquitous expression in placenta (RPKM 34.1), spleen (RPKM 33.9) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

PBX2 Products(1)

mRNA	Protein	Name
NM_002586.5	NP_002577.2	pre-B-cell leukemia transcription factor 2

PBX2 Protein Structure

PBC

Homeobox

0
100
200
300
400
430 a.a.

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor 2

XXbac-BPG300A18.13

Related Diseases

Diseases

Alias

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10107	PBX2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PBX2	VGNC	VGNC:75771
Mus musculus	PBX2	MGD	MGI:1341793
Canis familiaris	PBX2	VGNC	VGNC:44287
Bos taurus	PBX2	VGNC	VGNC:32608
Rattus norvegicus	PBX2	RGD	RGD:1303084
Felis catus	PBX2	VGNC	VGNC:68707