PBX2 - PBX homeobox 2 Gene

Also Known as G17; HOX12; PBX2MHC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5089

About PBX2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,184,733-32,190,202 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 132 orthologues and 12 paralogues. Ubiquitous expression in placenta (RPKM 34.1), spleen (RPKM 33.9) and 25 other tissues.

Summary

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

PBX2 Products (1)

mRNA	Protein	Name
NM_002586.5	NP_002577.2	pre-B-cell leukemia transcription factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19356220	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18973687	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12054735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19559479	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19356220	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18973687	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PBX2 Protein Structure

PBC

Homeobox

0
100
200
300
400
430 a.a.

Protein Preferred Names	Protein Names
pre-B-cell leukemia transcription factor 2	XXbac-BPG300A18.13

PBX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PBX2	P40425	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	PBX2	P40425	RIPPLY2	Homo sapiens	Q5TAB7	Complementation	32296183
Intra	PBX2	P40425	RIPPLY2	Homo sapiens	Q5TAB7	Validated Y2H	32296183
Intra	PBX2	P40425	PPFIBP1	Homo sapiens	Q86W92	Validated Y2H	32296183
Intra	PBX2	P40425	HOXC5	Homo sapiens	Q00444	Validated Y2H	32296183
Intra	PBX2	P40425	ZCWPW2	Homo sapiens	Q504Y3	Validated Y2H	32296183
Intra	PBX2	P40425	PKNOX1	Homo sapiens	P55347	Y2H	19559479
Intra	PBX2	P40425	TLX1	Homo sapiens	P31314	Y2H	19559479
Intra	PBX2	P40425	BLOC1S5	Homo sapiens	Q8TDH9	Validated Y2H	32296183
Intra	PBX2	P40425	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
Intra	PBX2	P40425	BRMS1L	Homo sapiens	Q5PSV4	Validated Y2H	32296183
Intra	PBX2	P40425	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	PBX2	P40425	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	PBX2	P40425	HOXA1	Homo sapiens	P49639	Validated Y2H	25416956
Intra	PBX2	P40425	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
Intra	PBX2	P40425	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
Intra	PBX2	P40425	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	PBX2	P40425	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PBX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810213	Pbx 2 Antibody (YA9557)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10107	PBX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PBX2	VGNC	VGNC:75771
Mus musculus	PBX2	MGD	MGI:1341793
Canis familiaris	PBX2	VGNC	VGNC:44287
Bos taurus	PBX2	VGNC	VGNC:32608
Rattus norvegicus	PBX2	RGD	RGD:1303084
Felis catus	PBX2	VGNC	VGNC:68707
Others	PBX2	NCBI