MCIDAS - multiciliate differentiation and DNA synthesis associated cell cycle protein Gene

Homo sapiens

Also known as MCI; IDAS; MCIN; CILD42

Gene ID: 345643 | Gene type: protein coding

About MCIDAS

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,219,564-55,227,315 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues, 2 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]

MCIDAS Products(1)

mRNA	Protein	Name
NM_001190787.3	NP_001177716.1	multicilin

MCIDAS Protein Structure

Geminin

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

multicilin

multiciliate cell differentiation 1

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 42

CILD42	Ciliary Dyskinesia, Primary, 42, Without Situs Inversus
Primary Ciliary Dyskinesia 42	Primary Ciliary Dyskinesia 42 Without Situs Inversus

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Ciliary Dyskinesia, Primary, 29

Primary Ciliary Dyskinesia 29	CILD29
Ciliary Dyskinesia, Primary, 29, Without Situs Inversus	Primary Ciliary Dyskinesia 29 Without Situs Inversus
Primary Ciliary Dyskinesia Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 29

Miles-Carpenter Syndrome

X-Linked Intellectual Disability, Miles-Carpenter Type	Mcs
Mental Retardation, X-Linked, Syndromic 4	Mental Retardation, X-Linked, With Congenital Contractures And Low Fingertip Arches
Mrxs4	Miles-Carpenter X-Linked Mental Retardation Syndrome

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Chronic Rhinitis

Rhinitis - Chronic	Chronic Rhinitis Nos
Rhinitis	Rhinitis Nos

Infertility

Hyperoxaluria, Primary, Type Iii

Primary Hyperoxaluria Type 3	HP3
Ph Iii	Primary Hyperoxaluria Type Iii
Hyperoxaluria Primary 3	Hyperoxaluria Non-Hp1/Non-Hp2
Hyperoxaluria Non-Ph I/Ph Ii Form	Hyperoxaluria Primary Type Iii

Kartagener Syndrome

Kartagener'S Syndrome

Cerebral Degeneration

Brain Degeneration

Degenerative Brain Disorder

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08229	MCIDAS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCIDAS	VGNC	VGNC:43078
Bos taurus	MCIDAS	VGNC	VGNC:31306
Macaca mulatta	MCIDAS	VGNC	VGNC:74637
Mus musculus	MCIDAS	MGD	MGI:3648807
Rattus norvegicus	MCIDAS	RGD	RGD:1584164

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