MCIDAS - multiciliate differentiation and DNA synthesis associated cell cycle protein Gene

Also Known as MCI; IDAS; MCIN; CILD42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 345643

About MCIDAS

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,219,564-55,227,315 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues, 2 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]

MCIDAS Products (1)

mRNA	Protein	Name
NM_001190787.3	NP_001177716.1	multicilin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21543332	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21543332	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in motile cilium assembly	IMP IMP: Inferred from mutant phenotype	25048963	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: Inferred from direct assay	24064211	GOA
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25048963	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	21543332	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21543332	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21543332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21543332	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCIDAS Protein Structure

Geminin

0
100
200
300
385 a.a.

Protein Preferred Names	Protein Names
multicilin	multiciliate cell differentiation 1

MCIDAS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCIDAS	D6RGH6	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	MCIDAS	D6RGH6	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	MCIDAS	D6RGH6	GMNN	Homo sapiens	O75496	Anti Tag CoIP	21543332
Intra	MCIDAS	D6RGH6	GMNN	Homo sapiens	O75496	Pull Down	21543332
Intra	MCIDAS	D6RGH6	MCIDAS	Homo sapiens	D6RGH6	Anti Tag CoIP	21543332
Intra	MCIDAS	D6RGH6	ZBTB24	Homo sapiens	O43167	Validated Y2H	32296183
Intra	MCIDAS	D6RGH6	MCIDAS	Homo sapiens	D6RGH6	Light Scattering	21543332

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 42	CILD42 Ciliary Dyskinesia, Primary, 42, Without Situs Inversus Primary Ciliary Dyskinesia 42 Primary Ciliary Dyskinesia 42 Without Situs Inversus
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Ciliary Dyskinesia, Primary, 29	Primary Ciliary Dyskinesia 29 CILD29 Ciliary Dyskinesia, Primary, 29, Without Situs Inversus Primary Ciliary Dyskinesia 29 Without Situs Inversus Primary Ciliary Dyskinesia Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 29
Miles-Carpenter Syndrome	X-Linked Intellectual Disability, Miles-Carpenter Type Mcs Mental Retardation, X-Linked, Syndromic 4 Mental Retardation, X-Linked, With Congenital Contractures And Low Fingertip Arches Mrxs4 Miles-Carpenter X-Linked Mental Retardation Syndrome
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Chronic Rhinitis	Rhinitis - Chronic Chronic Rhinitis Nos Rhinitis Rhinitis Nos
Infertility
Hyperoxaluria, Primary, Type Iii	Primary Hyperoxaluria Type 3 HP3 Ph Iii Primary Hyperoxaluria Type Iii Hyperoxaluria Primary 3 Hyperoxaluria Non-Hp1/Non-Hp2 Hyperoxaluria Non-Ph I/Ph Ii Form Hyperoxaluria Primary Type Iii
Kartagener Syndrome	Kartagener'S Syndrome
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08229	MCIDAS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCIDAS	VGNC	VGNC:43078
Bos taurus	MCIDAS	VGNC	VGNC:31306
Macaca mulatta	MCIDAS	VGNC	VGNC:74637
Mus musculus	MCIDAS	MGD	MGI:3648807
Rattus norvegicus	MCIDAS	RGD	RGD:1584164
Others	MCIDAS	NCBI