SAPCD2 - suppressor APC domain containing 2 Gene

Also Known as p42.3; C9orf140

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89958

Summary

Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. Located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in brain (RPKM 4.5), colon (RPKM 2.8) and 17 other tissues.

SAPCD2 Products (1)

mRNA Protein Name
NM_178448.4 NP_848543.2 suppressor APC domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26766442 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein localization to cell cortex IMP
IMP: Inferred from mutant phenotype
26766442 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23576022 GOA
Cellular Component GO Annotation Evidence References Source
located in apical cortex IDA
IDA: Inferred from direct assay
26766442 GOA
located in apical junction complex IDA
IDA: Inferred from direct assay
26766442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAPCD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SAPCD2 Q86UD0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 GMNN Homo sapiens O75496
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 GMNN Homo sapiens O75496
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra
SAPCD2 Q86UD0 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
Intra
SAPCD2 Q86UD0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
SAPCD2 Q86UD0 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
SAPCD2 Q86UD0 RALBP1 Homo sapiens Q15311
Y2H Array
32296183
Intra
SAPCD2 Q86UD0 RALBP1 Homo sapiens Q15311
Y2H Prey Pooling
32296183
Intra
SAPCD2 Q86UD0 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction