NAF1 - nuclear assembly factor 1 ribonucleoprotein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92345

About NAF1

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,103,929-163,166,890 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in testis (RPKM 1.9), endometrium (RPKM 1.8) and 25 other tissues.

Summary

Enables identical protein binding activity and Telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and Telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

NAF1 Products (2)

mRNA Protein Name
NM_001128931.2 NP_001122403.1 H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform b
NM_138386.3 NP_612395.2 H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
16618814 GOA
enables RNA binding IPI
IPI: Inferred from physical interaction
18082603 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16601202 GOA
enables telomerase RNA binding IPI
IPI: Inferred from physical interaction
18082603 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
27510903 GOA
acts upstream of positive regulation of telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
27510903 GOA
involved in ribosome biogenesis IDA
IDA: Inferred from direct assay
16618814 GOA
involved in telomerase RNA stabilization IMP
IMP: Inferred from mutant phenotype
27510903 GOA
involved in telomerase holoenzyme complex assembly IMP
IMP: Inferred from mutant phenotype
27510903 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
27510903 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
27510903 GOA
part of sno(s)RNA-containing ribonucleoprotein complex IDA
IDA: Inferred from direct assay
16601202 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAF1 Protein Structure

Gar1

Gar1: Gar1/Naf1 RNA binding region (179 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

H/ACA ribonucleoprotein complex non-core subunit NAF1

  • nuclear assembly factor 1 homolog

NAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAF1 Q96HR8 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
NAF1 Q96HR8 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra
NAF1 Q96HR8 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
NAF1 Q96HR8 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
NAF1 Q96HR8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
NAF1 Q96HR8 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra
NAF1 Q96HR8 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
NAF1 Q96HR8 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra
NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Anti Tag CoIP
26496610
Intra
NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Y2H Array
32296183
Intra
NAF1 Q96HR8 NOP10 Homo sapiens Q9NPE3
Anti Tag CoIP
26496610
Intra
NAF1 Q96HR8 NOP10 Homo sapiens Q9NPE3
Anti Bait CoIP
16601202
Intra
NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Tag CoIP
26496610
Intra
NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Bait CoIP
16601202
Intra
NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Bait CoIP
19179534
Intra
NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
Intra
NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra
NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Validated Y2H
32296183
Intra
NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Y2H Array
32296183
Intra
NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
NAF1 Q96HR8 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
NAF1 Q96HR8 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
NAF1 Q96HR8 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
NAF1 Q96HR8 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
NAF1 Q96HR8 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
NAF1 Q96HR8 DAB1 Homo sapiens O75553
Y2H Array
25416956
Cross
NAF1 Q96HR8 Dkc1 Rattus norvegicus P40615
Anti Bait CoIP
16618814
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02724 CISD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09008 NAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14834 TNIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19420 Cisd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NAF1 MGD MGI:2682306
Macaca mulatta NAF1 VGNC VGNC:75020
Rattus norvegicus NAF1 RGD RGD:1306802
Bos taurus NAF1 VGNC VGNC:54460
Felis catus NAF1 VGNC VGNC:63712
Others NAF1 NCBI