AK8 - adenylate kinase 8 Gene

Homo sapiens

Also known as AK 8; DDX31; C9orf98

Gene ID: 158067 | Gene type: protein coding

About AK8

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,725,578-132,879,046 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 9 paralogues. Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues.

Summary

Enables AMP binding activity and nucleobase-containing compound kinase activity. Involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2022]

AK8 Products(7)

mRNA	Protein	Name
NM_001317958.2	NP_001304887.1	adenylate kinase 8 isoform 2
NM_001317959.2	NP_001304888.1	adenylate kinase 8 isoform 3
NM_001371771.1	NP_001358700.1	adenylate kinase 8 isoform 4
NM_001371772.1	NP_001358701.1	adenylate kinase 8 isoform 5
NM_001371773.1	NP_001358702.1	adenylate kinase 8 isoform 2
NM_001371774.1	NP_001358703.1	adenylate kinase 8 isoform 2
NM_152572.3	NP_689785.1	adenylate kinase 8 isoform 1

AK8 Protein Structure

ADK

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

adenylate kinase 8

ATP-AMP transphosphorylase 8

Related Diseases

Diseases

Alias

Reticular Dysgenesis

Severe Combined Immunodeficiency With Leukopenia	De Vaal Disease
Congenital Aleukia	Aleukocytosis
Hematopoietic Hypoplasia, Generalized	Reticular Dysgenesia
Devaal Disease	Rd
Ak2 Deficiency	Congenital Aleukocytosis
Generalized Hematopoietic Hypoplasia	Scid With Leukopenia
RDYS

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00510	AK8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AK8	VGNC	VGNC:59709
Canis familiaris	AK8	VGNC	VGNC:37749
Mus musculus	AK8	MGD	MGI:1916120
Macaca mulatta	AK8	VGNC	VGNC:69710
Bos taurus	AK8	VGNC	VGNC:25777
Rattus norvegicus	AK8	RGD	RGD:1303144