AK8 - adenylate kinase 8 Gene

Also Known as AK 8; DDX31; C9orf98

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 158067

About AK8

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,725,578-132,879,046 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 9 paralogues. Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues.

Summary

Enables AMP binding activity and nucleobase-containing compound kinase activity. Involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2022]

AK8 Products (7)

mRNA Protein Name
NM_001317958.2 NP_001304887.1 adenylate kinase 8 isoform 2
NM_001317959.2 NP_001304888.1 adenylate kinase 8 isoform 3
NM_001371771.1 NP_001358700.1 adenylate kinase 8 isoform 4
NM_001371772.1 NP_001358701.1 adenylate kinase 8 isoform 5
NM_001371773.1 NP_001358702.1 adenylate kinase 8 isoform 2
NM_001371774.1 NP_001358703.1 adenylate kinase 8 isoform 2
NM_152572.3 NP_689785.1 adenylate kinase 8 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables (d)CMP kinase activity IDA
IDA: Inferred from direct assay
21080915 GOA
enables AMP binding IDA
IDA: Inferred from direct assay
33139725 GOA
enables adenylate kinase activity IDA
IDA: Inferred from direct assay
21080915 GOA
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
23416111 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
33139725 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AK8 Protein Structure

ADK

ADK: Adenylate kinase (62 - 234)

ADK

ADK: Adenylate kinase (273 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

adenylate kinase 8

  • ATP-AMP transphosphorylase 8

AK8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AK8 Q96MA6 CCDC102B Homo sapiens Q68D86
Validated Y2H
25416956
Intra
AK8 Q96MA6 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra
AK8 Q96MA6 MAP3K7CL Homo sapiens P57077-4
Y2H Prey Pooling
25416956
Intra
AK8 Q96MA6 MAP3K7CL Homo sapiens P57077-4
Validated Y2H
25416956
Intra
AK8 Q96MA6 MAP3K7CL Homo sapiens P57077-4
Y2H Array
25416956
Intra
AK8 Q96MA6 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra
AK8 Q96MA6 ERN1 Homo sapiens O75460-2
Validated Y2H
32814053
Intra
AK8 Q96MA6 ERN1 Homo sapiens O75460-2
Y2H Array
32814053
Intra
AK8 Q96MA6 ERN1 Homo sapiens O75460-2
Y2H Pooling
32814053
Intra
AK8 Q96MA6 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra
AK8 Q96MA6 SMG9 Homo sapiens Q9H0W8
Validated Y2H
32296183
Intra
AK8 Q96MA6 MCM7 Homo sapiens P33993
Validated Y2H
25416956
Intra
AK8 Q96MA6 MCM7 Homo sapiens P33993
Y2H Prey Pooling
25416956
Intra
AK8 Q96MA6 RBM39 Homo sapiens Q14498
Y2H Array
25416956
Intra
AK8 Q96MA6 RBM39 Homo sapiens Q14498
Y2H Prey Pooling
25416956
Intra
AK8 Q96MA6 RBM39 Homo sapiens Q14498-3
Y2H Array
25416956
Intra
AK8 Q96MA6 RBM39 Homo sapiens Q14498-3
Y2H Prey Pooling
25416956
Intra
AK8 Q96MA6 ALKBH3 Homo sapiens Q96Q83
Y2H Prey Pooling
25416956
Intra
AK8 Q96MA6 UBE2Z Homo sapiens Q9H832
Validated Y2H
25416956
Intra
AK8 Q96MA6 UBE2Z Homo sapiens Q9H832
Y2H Array
25416956
Intra
AK8 Q96MA6 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
Intra
AK8 Q96MA6 SYT17 Homo sapiens Q9BSW7
Validated Y2H
32296183
Intra
AK8 Q96MA6 MID1IP1 Homo sapiens Q9NPA3
Validated Y2H
25416956
Intra
AK8 Q96MA6 MID1IP1 Homo sapiens Q9NPA3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

AK8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810182 AK8 Antibody (YA9526) WB, IP, ELISA human

Related Diseases

Diseases Alias
Reticular Dysgenesis

  • Severe Combined Immunodeficiency With Leukopenia

  • De Vaal Disease

  • Congenital Aleukia

  • Aleukocytosis

  • Hematopoietic Hypoplasia, Generalized

  • Reticular Dysgenesia

  • Devaal Disease

  • Rd

  • Ak2 Deficiency

  • Congenital Aleukocytosis

  • Generalized Hematopoietic Hypoplasia

  • Scid With Leukopenia

  • RDYS
Ovary Serous Adenocarcinoma

  • Malignant Ovarian Serous Tumor

  • Serous Carcinoma Of Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00510 AK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AK8 VGNC VGNC:59709
Canis familiaris AK8 VGNC VGNC:37749
Mus musculus AK8 MGD MGI:1916120
Macaca mulatta AK8 VGNC VGNC:69710
Bos taurus AK8 VGNC VGNC:25777
Rattus norvegicus AK8 RGD RGD:1303144
Others AK8 NCBI