ALKBH3 - alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Gene

Also Known as ABH3; PCA1; DEPC1; hABH3; DEPC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221120

About ALKBH3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:43,880,831-43,920,274 (from NCBI)

This gene has 12 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in testis (RPKM 6.9), prostate (RPKM 6.8) and 25 other tissues.

Summary

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH3 Products (1)

mRNA Protein Name
NM_139178.4 NP_631917.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
12486230 GOA
enables broad specificity oxidative DNA demethylase activity IMP
IMP: Inferred from mutant phenotype
22055184 GOA
enables ferrous iron binding IDA
IDA: Inferred from direct assay
16858410 GOA
enables mRNA N1-methyladenosine dioxygenase activity IDA
IDA: Inferred from direct assay
26863196 GOA
enables oxidative RNA demethylase activity IDA
IDA: Inferred from direct assay
16174769 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22055184 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA alkylation repair IDA
IDA: Inferred from direct assay
20714506 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
22055184 GOA
involved in negative regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
26863196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH3 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (90 - 275)

  • 0
  • 100
  • 200
  • 286 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

  • alkB homolog 3, alpha-ketoglutaratedependent dioxygenase

ALKBH3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALKBH3 Q96Q83 GLRX3 Homo sapiens O76003
Y2H Array
25416956
Intra
ALKBH3 Q96Q83 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
ALKBH3 Q96Q83 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra
ALKBH3 Q96Q83 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
ALKBH3 Q96Q83 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
ALKBH3 Q96Q83 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
ALKBH3 Q96Q83 IKZF1 Homo sapiens Q13422
Y2H Array
25416956
Intra
ALKBH3 Q96Q83 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
ALKBH3 Q96Q83 AK8 Homo sapiens Q96MA6
Validated Y2H
25416956
Intra
ALKBH3 Q96Q83 AK8 Homo sapiens Q96MA6
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100199 HUHS015 99.32% Unkown
HY-173020 W23-1006 97.15% Unkown
HY-174979 Dac590 96.15% Unkown
HY-179266 FTO-IN-15 Inhibitor / Unkown
HY-RS00605 ALKBH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17256 Alkbh3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23710 Alkbh3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ALKBH3 VGNC VGNC:37804
Macaca mulatta ALKBH3 VGNC VGNC:69736
Felis catus ALKBH3 VGNC VGNC:59751
Mus musculus ALKBH3 MGD MGI:1916363
Bos taurus ALKBH3 VGNC VGNC:25834
Rattus norvegicus ALKBH3 RGD RGD:1359731
Others ALKBH3 NCBI