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HUHS015 

Cat. No.: HY-100199 Purity: 98.94%
Handling Instructions

HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1.

For research use only. We do not sell to patients.

HUHS015 Chemical Structure

HUHS015 Chemical Structure

CAS No. : 1453097-13-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 85 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 319 In-stock
Estimated Time of Arrival: December 31
100 mg USD 539 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1[1].

IC50 & Target

IC50: 0.67 μM (PCA-1)[1]

In Vitro

HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model[1].
HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice[1]
Dosage: 32 mg/kg
Administration: Subcutaneous injection; daily; 6 days
Result: Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.
Molecular Weight

318.37

Formula

C19H18N4O

CAS No.
SMILES

OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC=C(C)C=C4N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (106.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1410 mL 15.7050 mL 31.4100 mL
5 mM 0.6282 mL 3.1410 mL 6.2820 mL
10 mM 0.3141 mL 1.5705 mL 3.1410 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% saline

    Solubility: 5 mg/mL (15.70 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.85 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.85 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
HUHS015
Cat. No.:
HY-100199
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