FTO-IN-15
FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- Formula: C20H17Cl2N3O6
- Molecular Weight:466.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.3 μM[1]
FTO-IN-15 (compound 8a) (0-50 μM) functions as a competitive inhibitor for the 2-OG binding pocket of FTO, as evidenced by the dose-dependent reversal of its inhibitory activity by increasing concentrations of 2-OG in a cell-free enzymatic assay[1].
FTO-IN-15 exhibits potent FTO inhibitory activity, with an IC50 of 43.7 nM in a cell-free dot blot assay and 1.3 μM in a PAGE-based demethylation assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 466.27
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Formula C20H17Cl2N3O6
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SMILES
O=C(/C=C/C(NCCNC(C1=CC(Cl)=C(C(Cl)=C1)NC2=CC=CC=C2C(O)=O)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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