DPY30 - dpy-30 histone methyltransferase complex regulatory subunit Gene

Also Known as Cps25; Saf19; HDPY-30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84661

About DPY30

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,011,649-32,039,835 (from NCBI)

This gene has 7 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), adrenal (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

DPY30 Products (3)

mRNA Protein Name
NM_001321209.2 NP_001308138.1 protein dpy-30 homolog isoform 1
NM_001321210.2 NP_001308139.1 protein dpy-30 homolog isoform 2
NM_032574.4 NP_115963.1 protein dpy-30 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19556245 GOA
Biological Process GO Annotation Evidence References Source
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
19651892 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
19556245 GOA
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of MLL1/2 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of MLL3/4 complex IDA
IDA: Inferred from direct assay
17500065 GOA
part of MLL3/4 complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of Set1C/COMPASS complex IDA
IDA: Inferred from direct assay
18838538 GOA
part of Set1C/COMPASS complex IPI
IPI: Inferred from physical interaction
23508102 GOA
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
17500065 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17500065 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19651892 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPY30 Protein Structure

Dpy-30

Dpy-30: Dpy-30 motif (52 - 92)

  • 0
  • 99 a.a.
Protein Preferred Names Protein Names

protein dpy-30 homolog

  • dpy-30 homolog

DPY30 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPY30 Q9C005 PXN Homo sapiens P49023-2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 PXN Homo sapiens P49023-2
Y2H Array
32296183
Intra
DPY30 Q9C005 GTF2I Homo sapiens P78347-2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 GTF2I Homo sapiens P78347-2
Y2H Array
32296183
Intra
DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Validated Y2H
32296183
Intra
DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Y2H Array
32296183
Intra
DPY30 Q9C005 BEND3 Homo sapiens Q5T5X7
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 BEND3 Homo sapiens Q5T5X7
Y2H Array
32296183
Intra
DPY30 Q9C005 ICA1L Homo sapiens Q8NDH6-2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 ICA1L Homo sapiens Q8NDH6-2
Y2H Array
32296183
Intra
DPY30 Q9C005 AKAP8 Homo sapiens O43823
Anti Tag CoIP
23995757
Intra
DPY30 Q9C005 AKAP8 Homo sapiens O43823
Anti Bait CoIP
23995757
Intra
DPY30 Q9C005 TSPY2 Homo sapiens A6NKD2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 TSPY2 Homo sapiens A6NKD2
Y2H Array
32296183
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
Filter Binding
25456412
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
GMS
25456412
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
X-Ray Diffraction
25456412
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
Pull Down
25456412
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
GMS
31485071
Intra
DPY30 Q9C005 TSPY10 Homo sapiens P0CW01
Y2H Array
32296183
Intra
DPY30 Q9C005 TSPY10 Homo sapiens P0CW01
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 CFAP91 Homo sapiens Q7Z4T9
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 CFAP91 Homo sapiens Q7Z4T9
Y2H Array
32296183
Intra
DPY30 Q9C005 PSMC3 Homo sapiens P17980
Y2H Array
32296183
Intra
DPY30 Q9C005 PSMC3 Homo sapiens P17980
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 FAM136A Homo sapiens Q96C01
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 FAM136A Homo sapiens Q96C01
Y2H Array
32296183
Intra
DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Pull Down
25456412
Intra
DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Anti Tag CoIP
25456412
Intra
DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Anti Tag CoIP
23995757
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
17500065
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
25456412
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
23995757
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
31515488
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Validated Y2H
32296183
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Pull Down
17500065
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
32296183
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Fragment Pooling
23414517
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Prey Pooling
25416956
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
25416956
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Solution Sedimentation
19556245
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H
21516116
Intra
DPY30 Q9C005 ZFYVE19 Homo sapiens Q96K21
Y2H Array
32296183
Intra
DPY30 Q9C005 ZFYVE19 Homo sapiens Q96K21
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 RSPH3 Homo sapiens Q86UC2
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 RSPH3 Homo sapiens Q86UC2
Y2H Array
32296183
Intra
DPY30 Q9C005 PSMD14 Homo sapiens O00487
Validated Y2H
25416956
Intra
DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Prey Pooling
25416956
Intra
DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Array
32296183
Intra
DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Pooling
16189514
Intra
DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Solution Sedimentation
19556245
Intra
DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Pull Down
16189514
Intra
DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Y2H Pooling
16189514
Intra
DPY30 Q9C005 DYDC2 Homo sapiens Q96IM9
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 DYDC2 Homo sapiens Q96IM9
Y2H Array
32296183
Intra
DPY30 Q9C005 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 AK8 Homo sapiens Q96MA6
Y2H Array
32296183
Intra
DPY30 Q9C005 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra
DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Kabuki Syndrome 1

  • Kabuki Syndrome

  • Niikawa-Kuroki Syndrome

  • Kabuki Make-Up Syndrome

  • Kms

  • KABUK1

  • Kabuki Make Up Syndrome

  • Nks

  • Kabuki Makeup Syndrome

  • Kabuki Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03978 DPY30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20912 Dpy30 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27429 Dpy30 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27430 Duox2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPY30 VGNC VGNC:80086
Bos taurus DPY30 VGNC VGNC:50608
Mus musculus DPY30 MGD MGI:1913560
Rattus norvegicus DPY30 RGD RGD:708575
Canis familiaris DPY30 VGNC VGNC:49106
Macaca mulatta DPY30 VGNC VGNC:71898
Others DPY30 NCBI