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MRFAP1 - Morf4 family associated protein 1 Gene

Also Known as PGR1; PAM14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 93621

About MRFAP1

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,640,685-6,642,729 (from NCBI)

This gene has 4 transcripts (splice variants), 45 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 146.3), adrenal (RPKM 117.0) and 25 other tissues.

Summary

This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

MRFAP1 Products (2)

mRNA	Protein	Name
NM_001272053.2	NP_001258982.1	MORF4 family-associated protein 1 isoform a
NM_033296.3	NP_150638.1	MORF4 family-associated protein 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11500496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRFAP1 Protein Structure

MRFAP1

0
100
127 a.a.

Protein Preferred Names	Protein Names
MORF4 family-associated protein 1	Mof4 family associated protein 1

MRFAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRFAP1	Q9Y605	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	SLC	27107012
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	BFG-2H	27107012
Intra	MRFAP1	Q9Y605	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	25416956
Intra	MRFAP1	Q9Y605	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	C14orf93	Homo sapiens	Q9H972	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	UQCC2	Homo sapiens	Q9BRT2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	UQCC2	Homo sapiens	Q9BRT2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	TPM2	Homo sapiens	P07951-2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	TPM2	Homo sapiens	P07951-2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	FCHSD2	Homo sapiens	O94868-3	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	FCHSD2	Homo sapiens	O94868-3	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	PRAP1	Homo sapiens	Q96NZ9	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PRAP1	Homo sapiens	Q96NZ9	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	C3orf62	Homo sapiens	Q6ZUJ4	Validated Y2H	25416956
Intra	MRFAP1	Q9Y605	BRK1	Homo sapiens	Q8WUW1	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	BRK1	Homo sapiens	Q8WUW1	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	CAVIN3	Homo sapiens	Q969G5	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Anti Bait CoIP	17353931
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	MAPPIT	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Bait CoIP	17353931
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Pull Down	14506250
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	MAPPIT	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	25416956
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PCBD2	Homo sapiens	Q9H0N5	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PCBD2	Homo sapiens	Q9H0N5	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	SUV39H2	Homo sapiens	Q9H5I1	Anti Tag CoIP	23455924
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4270	Met-Arg-Phe-Ala	Inhibitor	99.77%	Unkown
HY-RS08645	MRFAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MRFAP1	RGD	RGD:628631
Mus musculus	MRFAP1	MGD	MGI:1914818