2. Gene
  3. SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KMT1B

Gene ID: 79723 | Gene type: protein coding

About SUV39H2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,878,866-14,904,315 (from NCBI)

This gene has 8 transcripts (splice variants), 145 orthologues and 19 paralogues. Broad expression in testis (RPKM 10.3), lymph node (RPKM 2.1) and 23 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity; Histone Methyltransferase activity (H3-K9 specific); and zinc ion binding activity. Involved in chromatin assembly or disassembly and chromatin remodeling. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUV39H2 Products(5)

mRNA Protein Name
NM_001193424.2 NP_001180353.1 histone-lysine N-methyltransferase SUV39H2 isoform 1
NM_001193425.2 NP_001180354.1 histone-lysine N-methyltransferase SUV39H2 isoform 2
NM_001193426.2 NP_001180355.1 histone-lysine N-methyltransferase SUV39H2 isoform 3
NM_001193427.2 NP_001180356.1 histone-lysine N-methyltransferase SUV39H2 isoform 4
NM_024670.4 NP_078946.1 histone-lysine N-methyltransferase SUV39H2 isoform 2

SUV39H2 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (47 - 94)

Pre-SET

Pre-SET: Pre-SET motif (147 - 242)

SET

SET: SET domain (262 - 373)

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  • 410 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SUV39H2

H3-K9-HMTase 2

Related Diseases

Diseases Alias
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122181B OTS186935 hydrochloride Inhibitor 99.22% Unkown
HY-13807 UNC0646 Inhibitor 99.82% Unkown
HY-122182 OTS193320 98.64% Unkown
HY-122181 OTS186935 Inhibitor / Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-RS14052 SUV39H2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SUV39H2 VGNC VGNC:35492
Macaca mulatta SUV39H2 VGNC VGNC:103876
Rattus norvegicus SUV39H2 RGD RGD:1306969
Felis catus SUV39H2 VGNC VGNC:65858
Canis familiaris SUV39H2 VGNC VGNC:84435
Mus musculus SUV39H2 MGD MGI:1890396