SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

Also Known as KMT1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79723

About SUV39H2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,878,866-14,904,315 (from NCBI)

This gene has 8 transcripts (splice variants), 145 orthologues and 19 paralogues. Broad expression in testis (RPKM 10.3), lymph node (RPKM 2.1) and 23 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity; Histone Methyltransferase activity (H3-K9 specific); and zinc ion binding activity. Involved in chromatin assembly or disassembly and chromatin remodeling. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUV39H2 Products (5)

mRNA	Protein	Name
NM_001193424.2	NP_001180353.1	histone-lysine N-methyltransferase SUV39H2 isoform 1
NM_001193425.2	NP_001180354.1	histone-lysine N-methyltransferase SUV39H2 isoform 2
NM_001193426.2	NP_001180355.1	histone-lysine N-methyltransferase SUV39H2 isoform 3
NM_001193427.2	NP_001180356.1	histone-lysine N-methyltransferase SUV39H2 isoform 4
NM_024670.4	NP_078946.1	histone-lysine N-methyltransferase SUV39H2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	20084102	GOA
enables histone H3K9 methyltransferase activity	IDA IDA: Inferred from direct assay	10949293	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	30111536	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	20084102	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to hypoxia	IDA IDA: Inferred from direct assay	21402781	GOA
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	10949293	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	10949293	GOA
involved in epigenetic programming in the zygotic pronuclei	IDA IDA: Inferred from direct assay	30111536	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21402781	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	10949293	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	30111536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUV39H2 Protein Structure

Chromo

Pre-SET

SET

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase SUV39H2	H3-K9-HMTase 2

SUV39H2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUV39H2	Q9H5I1	HEL25	Homo sapiens	V9HWG0	Y2H Array	25416956
Intra	SUV39H2	Q9H5I1	PHF19	Homo sapiens	Q5T6S3	Anti Tag CoIP	23455924
Intra	SUV39H2	Q9H5I1	PHF19	Homo sapiens	Q5T6S3	Y2H	23455924
Intra	SUV39H2	Q9H5I1	PNMA1	Homo sapiens	Q8ND90	MAPPIT	25416956
Intra	SUV39H2	Q9H5I1	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Y2H Array	31515488
Intra	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Validated Y2H	25416956
Intra	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Y2H Array	25416956
Intra	SUV39H2	Q9H5I1	KCTD17	Homo sapiens	Q8N5Z5	Y2H	23455924
Intra	SUV39H2	Q9H5I1	KCTD17	Homo sapiens	Q8N5Z5	Anti Tag CoIP	23455924
Intra	SUV39H2	Q9H5I1	KLHDC4	Homo sapiens	Q8TBB5	Anti Tag CoIP	23455924
Intra	SUV39H2	Q9H5I1	KLHDC4	Homo sapiens	Q8TBB5	Y2H	23455924
Intra	SUV39H2	Q9H5I1	MRFAP1	Homo sapiens	Q9Y605	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

SUV39H2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82137	KMT1B Antibody (YA1882)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122181	OTS186935	Inhibitor	99.69%	Unkown
HY-122181B	OTS186935 hydrochloride	Inhibitor	99.58%	Unkown
HY-13807	UNC0646	Inhibitor	99.38%	Unkown
HY-122182	OTS193320		98.12%	Unkown
HY-122181A	OTS186935 trihydrochloride	Inhibitor	/	Unkown
HY-13689G	Go 6983 (GMP)		/	Unkown
HY-RS14052	SUV39H2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185849	SETDB1-IN-1	Inhibitor	/	Unkown
HY-RS18319	Suv39h2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24797	Suv39h2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SUV39H2	VGNC	VGNC:35492
Macaca mulatta	SUV39H2	VGNC	VGNC:103876
Rattus norvegicus	SUV39H2	RGD	RGD:1306969
Felis catus	SUV39H2	VGNC	VGNC:65858
Canis familiaris	SUV39H2	VGNC	VGNC:84435
Mus musculus	SUV39H2	MGD	MGI:1890396
Others	SUV39H2	NCBI