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Cat. No.: HY-122181A

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OTS186935 trihydrochloride

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

OTS186935 trihydrochloride is a protein methyltransferase SUV39H2 inhibitor with an IC₅₀ of 6.49 nM. OTS186935 trihydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS186935 trihydrochloride regulates the production of γ-H2AX in cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2093401-85-3
Formula: C₂₅H₂₉Cl₄N₅O₂
Molecular Weight:573.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

OTS186935 trihydrochloride Chemical Structure

CAS No.: 2093401-85-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 6.49 nM (SUV39H2)^[1]

All Histone Methyltransferase Isoforms :

In Vitro

OTS186935 trihydrochloride inhibits A549 cell growth with IC₅₀ of 0.67 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OTS186935 trihydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )^[1]
Dosage:

10 mg/kg
Administration:

Intravenously; once daily for 14 days
Result:

Tumor growth inhibition of 42.6% on day 14.

Animal Model:

Female BALB/cAJcl-nu/nu mice (bearing A549 cells)^[1]
Dosage:

25 mg/kg
Administration:

Intravenously; once daily for 14 days
Result:

Yielded a tumor growth inhibition of 60.8% without significant body weight loss or toxicity.

Chemical Information

CAS No. 2093401-85-3
Molecular Weight 573.34
Formula C₂₅H₂₉Cl₄N₅O₂
SMILES

COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Mol Cell

DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states. [Abstract]

2024 Nov 25:S1097-2765(24)00914-6. PMID: 39631394
Acta Neuropathol

Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. [Abstract]

2022 Nov;144(5):1027-1048. PMID: 36070144
Cell Death Discov

CRISPR/Cas9 screening identifies SUV39H2 as a key regulator of oHSV-1 resistance in oral squamous cell carcinoma. [Abstract]

2025 Aug 23;11(1):402. PMID: 40849299
Research Square Preprint

2024 Feb 7.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

OTS186935 trihydrochloride

4 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Purity & Documentation
References

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OTS186935 trihydrochloride

Publications Citing Use of MedChemExpress (MCE) OTS186935 trihydrochloride

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Publications (4)

Purity & Documentation

References

Calculators

Help & FAQs

OTS186935 trihydrochloride Related Classifications

HY-122181A Related Classifications