1. Epigenetics
  2. Histone Methyltransferase
  3. OTS186935

OTS186935 

Cat. No.: HY-122181
Handling Instructions

OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM.

For research use only. We do not sell to patients.

OTS186935 Chemical Structure

OTS186935 Chemical Structure

CAS No. : 2093400-18-9

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  • Biological Activity

  • Technical Information

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Description

OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].

IC50 & Target

IC50: 6.49 nM (SUV39H2)[1]

In Vitro

OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].

In Vivo

OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

463.96

Formula

C₂₅H₂₆ClN₅O₂

CAS No.

2093400-18-9

SMILES

COC1=C(Cl)C=C(C2=CN3C=CC(N4C[[email protected]@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
OTS186935
Cat. No.:
HY-122181
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OTS186935

Cat. No.: HY-122181