2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. KMT1B Antibody (YA1882)

KMT1B Antibody (YA1882) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KMT1B.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

KMT1B Antibody (YA1882) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KMT1B.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 47 kDa;
Observed band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human KMT1B / SUV39H2 aa350-410/410.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation
Subcellular Localization：Nucleus; Chromosome, centromere
Isoforms & Post-Translational Modification：Q9H5I1 has 3 isomers: Q9H5I1-1: 46682 Da (predicted); Q9H5I1-2: 39946 Da (predicted); Q9H5I1-3: 26350 Da (predicted).
Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation
Subunit：Interacts with SMAD5.
Database

Entrez Gene: 79723 Human ; 64707 Mouse ; 364785 Rat

SwissProt: Q9H5I1 Human ; Q9EQQ0 Mouse ;

OMIM: 606503 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2
Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)
References

KMT1B Antibody (YA1882) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KMT1B Antibody (YA1882)
Cat. No.:
HY-P82137
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