KMT1B Antibody (YA1882)
(Synonyms: H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2)
Based on 1 Customer Validation
KMT1B Antibody (YA1882) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KMT1B.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50 |
Product Details
KMT1B Antibody (YA1882) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KMT1B.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 47 kDa
Entrez Gene: 79723 Human ; 64707 Mouse ; 364785 Rat
SwissProt: Q9H5I1 Human ; Q9EQQ0 Mouse ;
OMIM: 606503 Human
A synthesized peptide derived from human KMT1B / SUV39H2 aa350-410/410.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KMT1B is a Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation
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Subcellular Localization
Nucleus; Chromosome, centromere
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Isoforms & Post-Translational Modification
Q9H5I1 has 3 isomers: Q9H5I1-1: 46682 Da (predicted); Q9H5I1-2: 39946 Da (predicted); Q9H5I1-3: 26350 Da (predicted).
Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation -
Subunit
Interacts with SMAD5.
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SwissProt ID
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Synonyms
H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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