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Cat. No.: HY-185849

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SETDB1-IN-1

SETDB1-IN-1 is a SETDB1 inhibitor with an IC₅₀ of 16 μM. SETDB1-IN-1 inhibits histone methyltransferase) activity via SAM-competitive and peptide-dependent mechanisms. SETDB1-IN-1 is applicable to research related to melanoma, lung cancer, liver cancer, breast cancer and prostate cancer.

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CAS No.: 2585194-96-1
Formule: C₁₂H₁₈ClFN₆O₂S
Masse moléculaire:364.83

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Please store the product under the recommended conditions in the Certificate of Analysis.

SETDB1-IN-1 Chemical Structure

CAS No.: 2585194-96-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

In Vitro

SETDB1-IN-1 (Compound 7) exhibits limited selectivity in a panel of 16 purified methyltransferases, and shows potent inhibitory activity against SETDB1, SUV39H1, SUV39H2, PRMT7 and PRMT1^[1].
SETDB1-IN-1 is a peptide-dependent, SAM-competitive inhibitor of purified recombinant SETDB1 (570-1291)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2585194-96-1
Masse moléculaire 364.83
Formule C₁₂H₁₈ClFN₆O₂S
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O)[C@@H](CSCCN)O3.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Labbe, Marc-Olivier, et al. Identification of a C2′-fluorinated SAH analogue." Canadian Journal of Chemistry 98.6 (2020): 318-321.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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SETDB1-IN-1

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SETDB1-IN-1 Related Classifications

HY-185849 Related Classifications