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PHF19 - PHD finger protein 19 Gene

Also Known as PCL3; MTF2L1; TDRD19B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26147

About PHF19

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,855,651-120,904,128 (from NCBI)

This gene has 14 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 8.7), ovary (RPKM 6.6) and 24 other tissues.

Summary

Enables methylated histone binding activity. Involved in positive regulation of histone H3-K27 methylation. Colocalizes with ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF19 Products (5)

mRNA	Protein	Name
NM_001009936.3	NP_001009936.1	PHD finger protein 19 isoform b
NM_001286840.1	NP_001273769.1	PHD finger protein 19 isoform c
NM_001286842.1	NP_001273771.1	PHD finger protein 19 isoform d
NM_001286843.2	NP_001273772.1	PHD finger protein 19 isoform e
NM_015651.3	NP_056466.1	PHD finger protein 19 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	23104054	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23104054	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	23104054	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	23104054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF19 Protein Structure

PHD

Mtf2_C

0
100
200
300
400
500
580 a.a.

Protein Preferred Names	Protein Names
PHD finger protein 19	polycomb like 3

PHF19 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHF19	Q5T6S3	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	PHF19	Q5T6S3	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	POTEB3	Homo sapiens	A0JP26	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	POTEB3	Homo sapiens	A0JP26	Y2H Array	32296183
Intra	PHF19	Q5T6S3	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	PHF19	Q5T6S3	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	PHF19	Q5T6S3	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	PHF19	Q5T6S3	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	PHF19	Q5T6S3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	PHF19	Q5T6S3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	PHF19	Q5T6S3	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	PHF19	Q5T6S3	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	PHF19	Q5T6S3	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	PHF19	Q5T6S3	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	PHF19	Q5T6S3	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	PHF19	Q5T6S3	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	PHF19	Q5T6S3	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	PHF19	Q5T6S3	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	PHF19	Q5T6S3	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	PHF19	Q5T6S3	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	PHF19	Q5T6S3	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	PHF19	Q5T6S3	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	PHF19	Q5T6S3	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	PHF19	Q5T6S3	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
Intra	PHF19	Q5T6S3	INO80E	Homo sapiens	Q8NBZ0	Y2H Array	32296183
Intra	PHF19	Q5T6S3	INO80E	Homo sapiens	Q8NBZ0	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	INO80E	Homo sapiens	Q8NBZ0	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	PHF19	Q5T6S3	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	PHF19	Q5T6S3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183
Intra	PHF19	Q5T6S3	TSPYL2	Homo sapiens	Q9H2G4	Validated Y2H	32296183
Intra	PHF19	Q5T6S3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181914	UNC7242	Antagonist	/	Unkown
HY-RS10419	PHF19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22723	Phf19 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29237	Phf19 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHF19	VGNC	VGNC:64140
Bos taurus	PHF19	VGNC	VGNC:32817
Mus musculus	PHF19	MGD	MGI:1921266
Macaca mulatta	PHF19	VGNC	VGNC:75857
Canis familiaris	PHF19	VGNC	VGNC:59040
Rattus norvegicus	PHF19	RGD	RGD:1310390
Others	PHF19	NCBI