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INO80E - INO80 complex subunit E Gene

Also Known as CCDC95

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283899

About INO80E

This gene has 14 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in testis (RPKM 18.0), spleen (RPKM 15.7) and 25 other tissues.

Summary

Predicted to be involved in DNA recombination; DNA repair; and chromatin remodeling. Located in nucleolus and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

INO80E Products (3)

mRNA	Protein	Name
NM_001304562.2	NP_001291491.1	INO80 complex subunit E isoform 2
NM_001304563.2	NP_001291492.1	INO80 complex subunit E isoform 3
NM_173618.3	NP_775889.1	INO80 complex subunit E isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16230350	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	21303910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
INO80 complex subunit E	coiled-coil domain containing 95

INO80E Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INO80E	Q8NBZ0	TBRG1	Homo sapiens	Q05BL0	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	TBRG1	Homo sapiens	Q05BL0	Y2H Prey Pooling	25416956
Intra	INO80E	Q8NBZ0	MORN4	Homo sapiens	Q8NDC4	Y2H Prey Pooling	25416956
Intra	INO80E	Q8NBZ0	MORN4	Homo sapiens	Q8NDC4	Y2H Array	25416956
Intra	INO80E	Q8NBZ0	TNFAIP8	Homo sapiens	O95379	Y2H Prey Pooling	25416956
Intra	INO80E	Q8NBZ0	TNFAIP8	Homo sapiens	O95379	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	21303910
Intra	INO80E	Q8NBZ0	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	33961781
Intra	INO80E	Q8NBZ0	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	18922472
Intra	INO80E	Q8NBZ0	PRKAA1	Homo sapiens	Q13131	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	INO80E	Q8NBZ0	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	18922472
Intra	INO80E	Q8NBZ0	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	21303910
Intra	INO80E	Q8NBZ0	MCRS1	Homo sapiens	Q96EZ8	Anti Bait CoIP	16230350
Intra	INO80E	Q8NBZ0	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	33961781
Intra	INO80E	Q8NBZ0	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	INO80E	Q8NBZ0	KPNA2	Homo sapiens	P52292	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	INO80E	Q8NBZ0	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	INO80E	Q8NBZ0	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	INO80E	Q8NBZ0	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	INO80E	Q8NBZ0	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	INO80E	Q8NBZ0	GEM	Homo sapiens	P55040	Y2H Array	25416956
Intra	INO80E	Q8NBZ0	FAM124A	Homo sapiens	Q86V42	Y2H Prey Pooling	25416956
Intra	INO80E	Q8NBZ0	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
Intra	INO80E	Q8NBZ0	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia 3	SCZD3 Schizophrenia Susceptibility Locus, Chromosome 6-Related Schizophrenia 3 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06823	INO80E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INO80E	RGD	RGD:1359572
Bos taurus	INO80E	VGNC	VGNC:30207
Macaca mulatta	INO80E	VGNC	VGNC:73663
Felis catus	INO80E	VGNC	VGNC:62928
Mus musculus	INO80E	MGD	MGI:2141881
Canis familiaris	INO80E	VGNC	VGNC:42026
Others	INO80E	NCBI