2. Gene
  3. CDC23 - cell division cycle 23 Gene

CDC23 - cell division cycle 23 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APC8; CUT23; ANAPC8

Gene ID: 8697 | Gene type: protein coding

About CDC23

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,187,650-138,213,323 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

CDC23 Products(1)

mRNA Protein Name
NM_004661.4 NP_004652.2 cell division cycle protein 23 homolog

CDC23 Protein Structure

ANAPC8

ANAPC8: Anaphase promoting complex subunit 8 / Cdc23 (28 - 151)

TPR_1

TPR_1: Tetratricopeptide repeat (332 - 364)

TPR_11

TPR_11: TPR repeat (367 - 430)

TPR_1

TPR_1: Tetratricopeptide repeat (438 - 459)

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  • 597 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 23 homolog

anaphase-promoting complex subunit 8

Related Diseases

Diseases Alias
Neurotic Excoriation

Factitious Skin Disease

Dermatitis Artefacta

Dermatitis Factitia

Dermatitis Ficta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02290 CDC23 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDC23 RGD RGD:1304819
Mus musculus CDC23 MGD MGI:1098815
Felis catus CDC23 VGNC VGNC:82463
Bos taurus CDC23 VGNC VGNC:50038
Macaca mulatta CDC23 VGNC VGNC:70793
Canis familiaris CDC23 VGNC VGNC:51703