CYB5R2 - cytochrome b5 reductase 2 Gene

Also Known as B5R.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51700

About CYB5R2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,665,095-7,674,267 (from NCBI)

This gene has 14 transcripts (splice variants), 184 orthologues and 5 paralogues. Biased expression in testis (RPKM 34.1), skin (RPKM 7.5) and 8 other tissues.

Summary

The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including Cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

CYB5R2 Products (3)

mRNA	Protein	Name
NM_001302826.2	NP_001289755.1	NADH-cytochrome b5 reductase 2 isoform 1
NM_001302827.1	NP_001289756.1	NADH-cytochrome b5 reductase 2 isoform 2
NM_016229.5	NP_057313.2	NADH-cytochrome b5 reductase 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytochrome-b5 reductase activity, acting on NAD(P)H	IDA IDA: Inferred from direct assay	10611283	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	10611283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYB5R2 Protein Structure

FAD_binding_6

NAD_binding_1

0
100
200
276 a.a.

Protein Preferred Names	Protein Names
NADH-cytochrome b5 reductase 2	cytochrome b5 reductase b5R.2

CYB5R2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CYB5R2	Q6BCY4	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	CYB5R2	Q6BCY4	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	CYB5R2	Q6BCY4	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	CYB5R2	Q6BCY4	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	CYB5R2	Q6BCY4	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	CYB5R2	Q6BCY4	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Methemoglobinemia
Hemoglobinopathy	Hemoglobinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03420	CYB5R2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CYB5R2	VGNC	VGNC:50282
Rattus norvegicus	CYB5R2	RGD	RGD:1308421
Felis catus	CYB5R2	VGNC	VGNC:61310
Bos taurus	CYB5R2	VGNC	VGNC:50263
Mus musculus	CYB5R2	MGD	MGI:2444415
Macaca mulatta	CYB5R2	VGNC	VGNC:71519
Others	CYB5R2	NCBI