2. Gene
  3. CYB5R2 - cytochrome b5 reductase 2 Gene

CYB5R2 - cytochrome b5 reductase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B5R.2

Gene ID: 51700 | Gene type: protein coding

About CYB5R2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,665,095-7,674,267 (from NCBI)

This gene has 14 transcripts (splice variants), 184 orthologues and 5 paralogues. Biased expression in testis (RPKM 34.1), skin (RPKM 7.5) and 8 other tissues.

Summary

The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including Cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

CYB5R2 Products(3)

mRNA Protein Name
NM_001302826.2 NP_001289755.1 NADH-cytochrome b5 reductase 2 isoform 1
NM_001302827.1 NP_001289756.1 NADH-cytochrome b5 reductase 2 isoform 2
NM_016229.5 NP_057313.2 NADH-cytochrome b5 reductase 2 isoform 1

CYB5R2 Protein Structure

FAD_binding_6

FAD_binding_6: Oxidoreductase FAD-binding domain (20 - 126)

NAD_binding_1

NAD_binding_1: Oxidoreductase NAD-binding domain (152 - 259)

  • 0
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  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

NADH-cytochrome b5 reductase 2

cytochrome b5 reductase b5R.2

Related Diseases

Diseases Alias
Methemoglobinemia
Hemoglobinopathy

Hemoglobinopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03420 CYB5R2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CYB5R2 VGNC VGNC:50282
Rattus norvegicus CYB5R2 RGD RGD:1308421
Felis catus CYB5R2 VGNC VGNC:61310
Bos taurus CYB5R2 VGNC VGNC:50263
Mus musculus CYB5R2 MGD MGI:2444415
Macaca mulatta CYB5R2 VGNC VGNC:71519