CCDC125 - coiled-coil domain containing 125 Gene
Also Known as KENAE
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 202243
Summary
Enables identical protein binding activity. Involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in bone marrow (RPKM 4.7), prostate (RPKM 4.2) and 25 other tissues.
CCDC125 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001297696.2 | NP_001284625.1 | coiled-coil domain-containing protein 125 isoform 2 |
| NM_001297697.2 | NP_001284626.1 | coiled-coil domain-containing protein 125 isoform 3 |
| NM_176816.5 | NP_789786.2 | coiled-coil domain-containing protein 125 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in activation of GTPase activity |
IDA
IDA: Inferred from direct assay
|
19787194 | GOA |
| involved in negative regulation of Rho protein signal transduction |
IDA
IDA: Inferred from direct assay
|
19787194 | GOA |
| involved in negative regulation of cell motility |
IDA
IDA: Inferred from direct assay
|
19787194 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
19787194 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
CCDC125 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCDC125 | Q86Z20 | ZNF343 | Homo sapiens | Q6P1L6 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF343 | Homo sapiens | Q6P1L6 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF564 | Homo sapiens | Q8TBZ8 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | GAS8 | Homo sapiens | O95995 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | GAS8 | Homo sapiens | O95995 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF557 | Homo sapiens | Q8N988-2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | PKP2 | Homo sapiens | Q99959-2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF230 | Homo sapiens | Q9UIE0 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | NSD1 | Homo sapiens | Q96L73-2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | HAPLN2 | Homo sapiens | Q9GZV7 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | AIRIM | Homo sapiens | Q9NX04 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | CEP95 | Homo sapiens | Q96GE4 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | FAM161B | Homo sapiens | Q96MY7 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | C22orf15 | Homo sapiens | Q8WYQ4-2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | CDC23 | Homo sapiens | Q9UJX2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | FAM47B | Homo sapiens | Q8NA70 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | RIPOR3 | Homo sapiens | Q96MK2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | SPMIP2 | Homo sapiens | Q96LM5 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | OTOS | Homo sapiens | Q8NHW6 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAH | Homo sapiens | Q04917 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAH | Homo sapiens | Q04917 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAZ | Homo sapiens | P63104 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAZ | Homo sapiens | P63104 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | UACA | Homo sapiens | Q9BZF9 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAE | Homo sapiens | P62258 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAE | Homo sapiens | P62258 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAQ | Homo sapiens | P27348 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | YWHAQ | Homo sapiens | P27348 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | KAT5 | Homo sapiens | Q92993 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | SFN | Homo sapiens | P31947 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF587 | Homo sapiens | Q96SQ5 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | STX11 | Homo sapiens | O75558 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | STX11 | Homo sapiens | O75558 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF337 | Homo sapiens | Q9Y3M9 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | TCHP | Homo sapiens | Q9BT92 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF764 | Homo sapiens | Q96H86 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF764 | Homo sapiens | Q96H86 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | KIF9 | Homo sapiens | Q9HAQ2 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF436 | Homo sapiens | Q9C0F3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF436 | Homo sapiens | Q9C0F3 | 32296183 | |
|
Intra
|
CCDC125 | Q86Z20 | ZNF436 | Homo sapiens | Q9C0F3 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(8)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS02025 | CCDC115 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02026 | CCDC124 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02027 | CCDC127 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02034 | CCDC15 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02035 | CCDC152 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02041 | CCDC25 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19249 | Ccdc25 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS25738 | Ccdc25 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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