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ZNF436 - zinc finger protein 436 Gene

Also Known as ZNF; Zfp46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80818

About ZNF436

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,359,448-23,369,836 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 205 orthologues and 174 paralogues. Ubiquitous expression in ovary (RPKM 11.7), brain (RPKM 9.2) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF436 Products (3)

mRNA	Protein	Name
NM_001077195.2	NP_001070663.1	zinc finger protein 436 isoform 1
NM_001370652.1	NP_001357581.1	zinc finger protein 436 isoform 2
NM_030634.3	NP_085137.1	zinc finger protein 436 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF436 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
470 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 436	DNA-binding protein

ZNF436 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ZNF580	Homo sapiens	Q9UK33	Validated Y2H	32296183
Intra	ZNF436	Q9C0F3	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 55	Combined Immunodeficiency Due To Gins1 Deficiency IMD55 Cid Due To Gins1 Deficiency Combined Immunodeficiency With Intrauterine Growth Retardation-Nk Cell Deficiency-Neutropenia Combined Immunodeficiency With Intrauterine Growth Retardation-Natural Killer Cell Deficiency-Neutropenia
Myopathy, Tubular Aggregate, 1	Tubular Aggregate Myopathy Tam Myopathy With Tubular Aggregates TAM1 Myopathy, Tubular Aggregate Tubular Aggregate Myopathy 1
Autosomal Dominant Intellectual Developmental Disorder 40	Autosomal Dominant Non-Syndromic Intellectual Disability 40 Autosomal Dominant Mental Retardation 40 Mrd40 Mental Retardation, Autosomal Dominant 40

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16140	ZNF436 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNF436	VGNC	VGNC:100194
Bos taurus	ZNF436	VGNC	VGNC:37275
Canis familiaris	ZNF436	VGNC	VGNC:48727
Rattus norvegicus	ZNF436	RGD	RGD:1310584
Mus musculus	ZNF436	MGD	MGI:99192
Others	ZNF436	NCBI