country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

BCAS3 - BCAS3 microtubule associated cell migration factor Gene

Also Known as MAAB; GAOB1; PHAF2; HEMARS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54828

About BCAS3

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,677,851-61,392,831 (from NCBI)

This gene has 34 transcripts (splice variants), 212 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 4.9), brain (RPKM 4.0) and 25 other tissues.

Summary

Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and Histone Acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus; phagophore assembly site; and transcriptionally active chromatin. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BCAS3 Products (8)

mRNA	Protein	Name
NM_001099432.3	NP_001092902.1	BCAS3 microtubule associated cell migration factor isoform 1
NM_001320470.3	NP_001307399.1	BCAS3 microtubule associated cell migration factor isoform 3
NM_001330413.2	NP_001317342.1	BCAS3 microtubule associated cell migration factor isoform 4
NM_001330414.2	NP_001317343.1	BCAS3 microtubule associated cell migration factor isoform 5
NM_001353144.2	NP_001340073.1	BCAS3 microtubule associated cell migration factor isoform 6
NM_001353145.2	NP_001340074.1	BCAS3 microtubule associated cell migration factor isoform 7
NM_001353146.2	NP_001340075.1	BCAS3 microtubule associated cell migration factor isoform 8
NM_017679.5	NP_060149.3	BCAS3 microtubule associated cell migration factor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetyltransferase activator activity	IDA IDA: Inferred from direct assay	17505058	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	22300583	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	17505058	GOA
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	17505058	GOA
enables histone binding	IDA IDA: Inferred from direct assay	17505058	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	17505058	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	33499712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17505058	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	17505058	GOA
involved in positive regulation of catalytic activity	IDA IDA: Inferred from direct assay	17505058	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17505058	GOA
involved in response to estrogen	IDA IDA: Inferred from direct assay	16617102	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16617102	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	17505058	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16617102	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	33499712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAS3 Protein Structure

WD40

BCAS3

0
200
400
600
800
928 a.a.

Protein Preferred Names	Protein Names
BCAS3 microtubule associated cell migration factor	BCAS4/BCAS3 fusion

BCAS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCAS3	Q9H6U6	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
Intra	BCAS3	Q9H6U6	CTBP2	Homo sapiens	P56545-3	Validated Y2H	25416956
Intra	BCAS3	Q9H6U6	CTBP2	Homo sapiens	P56545-3	Y2H Array	25416956
Intra	BCAS3	Q9H6U6	VIM	Homo sapiens	P08670	Confocal	22300583
Intra	BCAS3	Q9H6U6	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	BCAS3	Q9H6U6	CDC23	Homo sapiens	Q9UJX2	Y2H Array	25416956
Intra	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	BCAS3	Q9H6U6	PHAF1	Homo sapiens	Q9BSU1	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hengel-Maroofian-Schols Syndrome	HEMARS Neurodevelopmental Disorder With Spasticity, Facial Dysmorphism, And Brain Abnormalities
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01401	BCAS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCAS3	MGD	MGI:2385848
Bos taurus	BCAS3	VGNC	VGNC:26438
Macaca mulatta	BCAS3	VGNC	VGNC:70073
Felis catus	BCAS3	VGNC	VGNC:60080
Rattus norvegicus	BCAS3	RGD	RGD:1560788
Canis familiaris	BCAS3	VGNC	VGNC:38400
Others	BCAS3	NCBI