PHAF1 - phagophore assembly factor 1 Gene

Also Known as LIN10; MYTHO; lin-10; C16orf6; C16orf70

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80262

Summary

Predicted to be involved in Golgi to plasma membrane protein transport. Located in phagophore assembly site. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in skin (RPKM 9.9), liver (RPKM 9.8) and 25 other tissues.

PHAF1 Products (5)

mRNA Protein Name
NM_001320540.2 NP_001307469.1 phagosome assembly factor 1 isoform a
NM_001320541.2 NP_001307470.1 phagosome assembly factor 1 isoform a
NM_001320542.2 NP_001307471.1 phagosome assembly factor 1 isoform a
NM_001320543.2 NP_001307472.1 phagosome assembly factor 1 isoform b
NM_025187.5 NP_079463.2 phagosome assembly factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Cellular Component GO Annotation Evidence References Source
located in phagophore assembly site IDA
IDA: Inferred from direct assay
33499712 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PHAF1 Q9BSU1 BCAS3 Homo sapiens Q9H6U6-2
Y2H Prey Pooling
25416956
Intra
PHAF1 Q9BSU1 BCAS3 Homo sapiens Q9H6U6-2
Validated Y2H
25416956
Intra
PHAF1 Q9BSU1 TSHZ2 Homo sapiens Q9NRE2
Validated Y2H
32296183
Intra
PHAF1 Q9BSU1 BCAS3 Homo sapiens Q9H6U6
Anti Tag CoIP
33961781
Intra
PHAF1 Q9BSU1 TOLLIP Homo sapiens Q9H0E2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10454 PHRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D3109 pH-Ap-1 / Unkown
HY-RS09966 PAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10413 PHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10455 PHTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18363 Paf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22728 Phrf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24842 Paf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29242 Phrf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown