INPP5J - inositol polyphosphate-5-phosphatase J Gene

Homo sapiens

Also known as PIPP; INPP5; PIB5PA

Gene ID: 27124 | Gene type: protein coding

About INPP5J

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,122,923-31,134,697 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 13 paralogues. Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues.

Summary

Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

INPP5J Products(6)

mRNA	Protein	Name
NM_001002837.2	NP_001002837.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c
NM_001284285.2	NP_001271214.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a
NM_001284286.1	NP_001271215.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b
NM_001284287.1	NP_001271216.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d
NM_001284288.1	NP_001271217.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e
NM_001284289.1	NP_001271218.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

INPP5J Protein Structure

Exo_endo_phos

0
200
400
600
800
1006 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Related Diseases

Diseases

Alias

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06832	INPP5J Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INPP5J	VGNC	VGNC:53909
Felis catus	INPP5J	VGNC	VGNC:68841
Canis familiaris	INPP5J	VGNC	VGNC:42035
Macaca mulatta	INPP5J	VGNC	VGNC:73814
Rattus norvegicus	INPP5J	RGD	RGD:620541
Mus musculus	INPP5J	MGD	MGI:2158663

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