Pellino-1
Pellino-1 (Peli1) is a RING-type E3 ubiquitin ligase positioned immediately downstream of Toll-like receptors and the interleukin-1 receptor. After IRAK1 phosphorylates and activates it, Pellino-1 builds K63-linked polyubiquitin chains on IRAK1, creating the scaffold that recruits TAK1 and the IKK complex and thereby launches NF-κB and MAPK signaling. It thus sets the amplitude of innate immune responses to microbial stimuli and has been implicated in autoimmune and inflammatory disease models, as well as in some lymphomas where Peli1 is amplified. Recombinant Pellino-1 is used to reconstitute IRAK1 ubiquitination in vitro and to screen pathway-selective anti-inflammatory inhibitors.
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Pellino-1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
