FXR2 - FMR1 autosomal homolog 2 Gene

Also Known as FXR2P; FMR1L2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9513

About FXR2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,591,230-7,614,897 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 19.4), testis (RPKM 17.3) and 25 other tissues.

Summary

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

FXR2 Products (1)

mRNA	Protein	Name
NM_004860.4	NP_004851.2	RNA-binding protein FXR2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7489725	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	7489725	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	7489725	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7489725	GOA
is active in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	12417522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FXR2 Protein Structure

Agenet

KH_1

FXMRP1_C_core

0
200
400
600
673 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein FXR2 fragile X mental retardation syndrome-related protein 2

Protein Preferred Names

Protein Names

RNA-binding protein FXR2

fragile X mental retardation syndrome-related protein 2

FXR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76-2	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76-2	Validated Y2H	25416956
Intra	FXR2	P51116	FMR1	Homo sapiens	Q06787-8	Validated Y2H	25416956
Intra	FXR2	P51116	INPP5J	Homo sapiens	Q15735	Validated Y2H	32296183
Intra	FXR2	P51116	MIA3	Homo sapiens	Q5JRA6-2	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Y2H Array	25416956
Intra	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	25416956
Intra	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
Intra	FXR2	P51116	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	FXR2	P51116	BAZ2B	Homo sapiens	Q9UIF8-2	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	MRPL43	Homo sapiens	Q8N983	Y2H Array	25416956
Intra	FXR2	P51116	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	MFAP1	Homo sapiens	P55081	Validated Y2H	32296183
Intra	FXR2	P51116	NEXN	Homo sapiens	Q0ZGT2-4	Validated Y2H	32296183
Intra	FXR2	P51116	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	FXR2	P51116	FMR1	Homo sapiens	Q8IXW7	Validated Y2H	32296183
Intra	FXR2	P51116	EIF4G1	Homo sapiens	Q04637-9	Validated Y2H	32296183
Intra	FXR2	P51116	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Cross	FXR2	P51116	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Y2H Array	36217030
Intra	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	FXR2	P51116	PAF1	Homo sapiens	Q8N7H5	Y2H Array	25416956
Intra	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
Intra	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	25416956
Intra	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32296183
Intra	FXR2	P51116	LCP2	Homo sapiens	Q13094	Validated Y2H	32296183
Intra	FXR2	P51116	LCP2	Homo sapiens	Q13094	Y2H Array	25416956
Intra	FXR2	P51116	UBAP2L	Homo sapiens	Q14157	Validated Y2H	32296183
Intra	FXR2	P51116	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	16189514
Intra	FXR2	P51116	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	FXR2	P51116	CAMK2D	Homo sapiens	Q13557	Y2H Array	25416956
Intra	FXR2	P51116	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	FXR2	P51116	FMR1	Homo sapiens	Q06787	Y2H Pooling	21653829
Intra	FXR2	P51116	FMR1	Homo sapiens	Q06787	Anti Tag CoIP	33961781
Intra	FXR2	P51116	FMR1	Homo sapiens	Q06787	TAP	24981860
Intra	FXR2	P51116	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	FXR2	P51116	CDKL3	Homo sapiens	Q8IVW4	Y2H Array	25416956
Intra	FXR2	P51116	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
Intra	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	19060904
Intra	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Pooling	19060904
Intra	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Pooling	16189514
Intra	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Y2H Array	25416956
Intra	FXR2	P51116	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
Intra	FXR2	P51116	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	SRPK2	Homo sapiens	P78362	Validated Y2H	25416956
Intra	FXR2	P51116	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	FXR2	P51116	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	PIM1	Homo sapiens	P11309	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Pooling	16189514
Intra	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Array	19060904
Intra	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Pooling	19060904
Intra	FXR2	P51116	PTS	Homo sapiens	Q03393	Y2H Array	31515488
Intra	FXR2	P51116	RABAC1	Homo sapiens	Q9UI14	Y2H Pooling	16189514
Intra	FXR2	P51116	FBP1	Homo sapiens	P09467	Y2H Array	31515488
Intra	FXR2	P51116	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	FXR2	P51116	FXR1	Homo sapiens	P51114	Anti Tag CoIP	33961781
Intra	FXR2	P51116	FXR1	Homo sapiens	P51114	Anti Tag CoIP	28514442
Intra	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Pooling	16189514
Intra	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Array	19060904
Intra	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Pooling	19060904
Intra	FXR2	P51116	ZBTB22	Homo sapiens	O15209	Validated Y2H	25416956
Intra	FXR2	P51116	ZBTB22	Homo sapiens	O15209	Y2H Array	25416956
Intra	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H Array	25416956
Intra	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H	21516116
Intra	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	CBS	Homo sapiens	P35520	Y2H Array	31515488
Intra	FXR2	P51116	PCBD1	Homo sapiens	P61457	Y2H Array	25416956
Intra	FXR2	P51116	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
Intra	FXR2	P51116	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
Intra	FXR2	P51116	NME1	Homo sapiens	P15531	Y2H Array	31515488
Intra	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Array	19060904
Intra	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	16189514
Intra	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	19060904
Intra	FXR2	P51116	NT5C2	Homo sapiens	P49902	Y2H Pooling	16189514
Intra	FXR2	P51116	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	25416956
Intra	FXR2	P51116	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
Intra	FXR2	P51116	LASP1	Homo sapiens	Q14847	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	LASP1	Homo sapiens	Q14847	Validated Y2H	25416956
Intra	FXR2	P51116	LASP1	Homo sapiens	Q14847	Y2H Array	25416956
Intra	FXR2	P51116	C10orf62	Homo sapiens	Q5T681	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	C10orf62	Homo sapiens	Q5T681	Y2H Pooling	16189514
Intra	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Validated Y2H	32296183
Intra	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Y2H Array	25416956
Intra	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Validated Y2H	25416956
Intra	FXR2	P51116	LCMT1	Homo sapiens	Q9UIC8	Y2H Pooling	16189514
Intra	FXR2	P51116	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
Intra	FXR2	P51116	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32296183
Intra	FXR2	P51116	SCEL	Homo sapiens	O95171	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	TBC1D22B	Homo sapiens	Q9NU19	Y2H Prey Pooling	25416956
Intra	FXR2	P51116	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Premature Ovarian Failure 1	Ovarian Failure, Premature Fmr1-Related Primary Ovarian Insufficiency Fragile X-Associated Primary Ovarian Insufficiency POF1 Pofx Hypergonadotropic Ovarian Failure, X-Linked Pof Primary Ovarian Insufficiency, Fragile X-Associated Primary Ovarian Insufficiency 1 Ovarian Failure Premature Premature Ovarian Failure, X-Linked Fragile X Premature Ovarian Failure Fmr1-Related Premature Ovarian Failure Familial Premature Ovarian Failure Idiopathic Familial Premature Ovarian Failure Fxpoi X-Linked Hypergonadotropic Ovarian Failure Hypergonadotropic Ovarian Failure X-Linked Poi Premature Ovarian Failure X-Linked Primary Ovarian Insufficiency Premature Ovarian Failure-1 Ovarian Failure, Premature, Type 1 Premature Ovarian Failure, Familial Premature Menopause Primary Hypogonadism Turner Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05164	FXR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FXR2	RGD	RGD:1307011
Bos taurus	FXR2	VGNC	VGNC:55832
Mus musculus	FXR2	MGD	MGI:1346074
Macaca mulatta	FXR2	VGNC	VGNC:99153
Canis familiaris	FXR2	VGNC	VGNC:53386
Felis catus	FXR2	VGNC	VGNC:99059
Others	FXR2	NCBI