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PAF1 - PAF1 homolog, Paf1/RNA polymerase II complex component Gene

Also Known as PD2; F23149_1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54623

About PAF1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,385,629-39,391,106 (from NCBI)

This gene has 8 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in testis (RPKM 32.1), ovary (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

PAF1 Products (2)

mRNA	Protein	Name
NM_001256826.2	NP_001243755.1	RNA polymerase II-associated factor 1 homolog isoform 2
NM_019088.4	NP_061961.2	RNA polymerase II-associated factor 1 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	15923622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	21329879	GOA
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	20541477	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15923622	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16307923	GOA
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	22046413	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	16307923	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22046413	GOA
located in membrane	IDA IDA: Inferred from direct assay	22046413	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAF1 Protein Structure

Paf1

0
100
200
300
400
500
531 a.a.

Protein Preferred Names	Protein Names
RNA polymerase II-associated factor 1 homolog	Paf1, RNA polymerase II associated factor, homolog

PAF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	RTF1	Homo sapiens	Q92541	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	LINC-PINT	Homo sapiens	A0A455ZAR2	Confocal	30367041
Intra	PAF1	Q8N7H5	LINC-PINT	Homo sapiens	A0A455ZAR2	Anti Tag CoIP	30367041
Intra	PAF1	Q8N7H5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	UBE2E1	Homo sapiens	P51965	Anti Bait CoIP	16307923
Intra	PAF1	Q8N7H5	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	25277244
Intra	PAF1	Q8N7H5	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	PAF1	Q8N7H5	KMT2A	Homo sapiens	Q03164	Anti Bait CoIP	20541477
Intra	PAF1	Q8N7H5	SKIC3	Homo sapiens	Q6PGP7	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	SKIC3	Homo sapiens	Q6PGP7	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	PAF1	Q8N7H5	FXR2	Homo sapiens	P51116	Y2H	21516116
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Pull Down	15923622
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	19410543
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	15923622
Intra	PAF1	Q8N7H5	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Bait CoIP	16024656
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	16024656
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Y2H Prey Pooling	25416956
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	TAP	24981860
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	20178742
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Validated Y2H	25416956
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Y2H Prey Pooling	32296183
Intra	PAF1	Q8N7H5	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	19410543
Cross	PAF1	Q8N7H5	NS1	Influenza A virus	B2BUF1	Anti Bait CoIP	22419161
Cross	PAF1	Q8N7H5	NS1	Influenza A virus	B2BUF1	Anti Tag CoIP	22419161

Cross: Cross-species interaction Intra: Intraspecies interaction

PAF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82760	PAF1 Antibody (YA2505)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 3	DBA3 Anemia, Diamond-Blackfan, 3 Rps24-Related Diamond-Blackfan Anemia Anemia Diamond-Blackfan 3 Anemia, Diamond-Blackfan, Type 3
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Otopalatodigital Syndrome, Type Ii	Otopalatodigital Syndrome Type 2 Faciopalatoosseous Syndrome OPD2 Opd Ii Syndrome Opd Syndrome 2 Cranioorodigital Syndrome Fpo Oto-Palato-Digital Syndrome, Type Ii Andre Syndrome Oto-Palato-Digital Syndrome Type 2 Otopalatodigital Syndrome Type Ii Cranio-Oro-Digital Syndrome Opd 2 Syndrome Opd Syndrome, Type 2 Taybi Syndrome Otopalatodigital Syndrome 2 Oto-Palato-Digital Syndrome, Type 2 Oto-Palato-Digital Syndrome Type 1
Retinitis Pigmentosa 40	RP40 Retinitis Pigmentosa-40 Retinitis Pigmentosa, Type 40
Malignant Fibrous Histiocytoma Of Bone	Malignant Fibrous Histiocytoma Of The Bone
Myopathy, Distal, 4	Distal Myopathy With Posterior Leg And Anterior Hand Involvement MPD4 Williams Distal Myopathy Distal Muscular Dystrophy 4 Distal Abd-Filaminopathy Distal Myopathy 4 Myopathy, Distal, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160267	iPAF1C		99.59%	Unkown
HY-P3103A	PINT-87aa TFA		≥99.0%	Unkown
HY-130345S	C18-PAF-d4		/	Unkown
HY-170229	C17 Lyso PAF		/	Unkown
HY-N17414	Preschisanartanin O		/	Unkown
HY-N2247A	(+)-Guaiacin		/	Unkown
HY-P3103	PINT-87aa		/	Unkown
HY-RS09966	PAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10348	PEX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106062	CV 3988	Inhibitor	/	Unkown
HY-134235	PAF C-16 carboxylic acid		/	Unkown
HY-RS18363	Paf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21406	Pex2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24842	Paf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAF1	RGD	RGD:1306219
Mus musculus	PAF1	MGD	MGI:1923988
Felis catus	PAF1	VGNC	VGNC:64024
Bos taurus	PAF1	VGNC	VGNC:96701
Macaca mulatta	PAF1	VGNC	VGNC:81492
Others	PAF1	NCBI