CTR9 - CTR9 homolog, Paf1/RNA polymerase II complex component Gene

Also Known as TSBP; p150; SH2BP1; p150TSP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9646

About CTR9

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:10,751,246-10,779,746 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 19.1), thyroid (RPKM 14.8) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. [provided by RefSeq, Oct 2016]

CTR9 Products (2)

mRNA Protein Name
NM_001346279.2 NP_001333208.1 RNA polymerase-associated protein CTR9 homolog isoform 2
NM_014633.5 NP_055448.1 RNA polymerase-associated protein CTR9 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15923622 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
20541477 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16307923 GOA
involved in stem cell population maintenance IDA
IDA: Inferred from direct assay
19345177 GOA
involved in transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
20178742 GOA
Cellular Component GO Annotation Evidence References Source
part of Cdc73/Paf1 complex IDA
IDA: Inferred from direct assay
16307923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTR9 Protein Structure

TPR_11

TPR_11: TPR repeat (168 - 228)

TPR_11

TPR_11: TPR repeat (305 - 372)

TPR_2

TPR_2: Tetratricopeptide repeat (451 - 479)

TPR_1

TPR_1: Tetratricopeptide repeat (501 - 530)

TPR_11

TPR_11: TPR repeat (533 - 589)

TPR_1

TPR_1: Tetratricopeptide repeat (682 - 709)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1173 a.a.
Protein Preferred Names Protein Names

RNA polymerase-associated protein CTR9 homolog

  • Ctr9, Paf1/RNA polymerase II complex component, homolog

CTR9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTR9 Q6PD62 PAF1 Homo sapiens Q8N7H5
Anti Tag CoIP
20178742
Intra
CTR9 Q6PD62 PAF1 Homo sapiens Q8N7H5
TAP
24981860
Intra
CTR9 Q6PD62 PAF1 Homo sapiens Q8N7H5
Anti Tag CoIP
26496610
Intra
CTR9 Q6PD62 SKIC8 Homo sapiens Q9GZS3
Anti Tag CoIP
26496610
Intra
CTR9 Q6PD62 SKIC8 Homo sapiens Q9GZS3
Anti Tag CoIP
20178742
Intra
CTR9 Q6PD62 SKIC8 Homo sapiens Q9GZS3
GMS
20178742
Intra
CTR9 Q6PD62 SKIC8 Homo sapiens Q9GZS3
TAP
24981860
Intra
CTR9 Q6PD62 KMT2A Homo sapiens Q03164
Anti Tag CoIP
20541477
Intra
CTR9 Q6PD62 CDC73 Homo sapiens Q6P1J9
TAP
24981860
Intra
CTR9 Q6PD62 CDC73 Homo sapiens Q6P1J9
Anti Tag CoIP
26496610
Intra
CTR9 Q6PD62 CDC73 Homo sapiens Q6P1J9
Anti Tag CoIP
20178742
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hereditary Wilms' Tumor

  • Hereditary Wilms Tumor

  • Hereditary Wilms Tumour

  • Hereditary Wilms' Tumour

  • Wt1
Malignant Fibrous Histiocytoma Of Bone

  • Malignant Fibrous Histiocytoma Of The Bone
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Cockayne Syndrome

  • Cockayne'S Syndrome

  • Dwarfism-Retinal Atrophy-Deafness Syndrome

  • Neill-Dingwall Syndrome

  • Progeria-Like Syndrome

  • Progeroid Nanism

  • Cs
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160267 iPAF1C 99.59% Unkown
HY-RS03316 CTR9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22131 Ctr9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CTR9 VGNC VGNC:61262
Rattus norvegicus CTR9 RGD RGD:1311097
Canis familiaris CTR9 VGNC VGNC:39706
Bos taurus CTR9 VGNC VGNC:27810
Mus musculus CTR9 MGD MGI:109345
Macaca mulatta CTR9 VGNC VGNC:71424