CDC73 - cell division cycle 73 Gene

Also Known as HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79577

About CDC73

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,122,031-193,254,815 (from NCBI)

This gene has 13 transcripts (splice variants), 215 orthologues and is associated with 92 phenotypes. Ubiquitous expression in thyroid (RPKM 11.2), prostate (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a Histone Methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

CDC73 Products (1)

mRNA	Protein	Name
NM_024529.5	NP_078805.3	parafibromin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	15923622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	21329879	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	16989776	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16989776	GOA
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18987311	GOA
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	18987311	GOA
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	20541477	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18987311	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16630820	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15923622	GOA
involved in positive regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19136632	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16307923	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	18987311	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	16307923	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15923622	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC73 Protein Structure

CDC73_C

0
100
200
300
400
500
531 a.a.

Protein Preferred Names	Protein Names
parafibromin	Familial isolated hyperparathyroidism

CDC73 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Bait CoIP	15923622
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	GMS	15923622
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	33961781
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	GMS	16024656
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	GMS	20178742
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	28514442
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	20178742
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Bait CoIP	19136632
Intra	CDC73	Q6P1J9	CTR9	Homo sapiens	Q6PD62	Anti Tag CoIP	26496610
Intra	CDC73	Q6P1J9	RTF1	Homo sapiens	Q92541	GMS	20178742
Intra	CDC73	Q6P1J9	RTF1	Homo sapiens	Q92541	Anti Tag CoIP	20178742
Intra	CDC73	Q6P1J9	RTF1	Homo sapiens	Q92541	GMS	15923622
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59-3	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	25910212
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	PTPN11	Homo sapiens	Q06124-2	Phosphatase Assay	26742426
Intra	CDC73	Q6P1J9	RNF20	Homo sapiens	Q5VTR2	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	RNF20	Homo sapiens	Q5VTR2	Y2H Array	32296183
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	15923622
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	TAP	24981860
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	GMS	20178742
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	26496610
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	19136632
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	33961781
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	GMS	15923622
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	GMS	16024656
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	28514442
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
Intra	CDC73	Q6P1J9	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	15923622
Intra	CDC73	Q6P1J9	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	26659056
Intra	CDC73	Q6P1J9	ALAS1	Homo sapiens	P13196	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	ALAS1	Homo sapiens	P13196	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	ALAS1	Homo sapiens	P13196	Y2H Array	25910212
Intra	CDC73	Q6P1J9	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	CDC73	Q6P1J9	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	25416956
Intra	CDC73	Q6P1J9	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	25416956
Intra	CDC73	Q6P1J9	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	CDC73	Q6P1J9	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	CTNNB1	Homo sapiens	P35222	Pull Down	16630820
Intra	CDC73	Q6P1J9	CTNNB1	Homo sapiens	P35222	Y2H	16630820
Intra	CDC73	Q6P1J9	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	16630820
Intra	CDC73	Q6P1J9	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	BCL9	Homo sapiens	O00512	Anti Tag CoIP	17113272
Intra	CDC73	Q6P1J9	BCL9	Homo sapiens	O00512	Anti Bait CoIP	16630820
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Y2H Array	25910212
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	CDC73	Q6P1J9	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	CDC73	Q6P1J9	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	20541477
Intra	CDC73	Q6P1J9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CDC73	Q6P1J9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Y2H Array	25910212
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CDC73	Q6P1J9	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CDC73	Q6P1J9	CSTF2	Homo sapiens	P33240	Density Sedimentation	19136632
Intra	CDC73	Q6P1J9	CSTF2	Homo sapiens	P33240	Anti Bait CoIP	19136632
Intra	CDC73	Q6P1J9	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	CDC73	Q6P1J9	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	CDC73	Q6P1J9	TFCP2	Homo sapiens	Q12800	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	TFCP2	Homo sapiens	Q12800	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	TFCP2	Homo sapiens	Q12800	Y2H Array	25910212
Intra	CDC73	Q6P1J9	CPSF4	Homo sapiens	O95639	Anti Bait CoIP	19136632
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25910212
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Y2H	21900206
Intra	CDC73	Q6P1J9	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	CDC73	Q6P1J9	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	CDC73	Q6P1J9	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	29774127
Intra	CDC73	Q6P1J9	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	TSGA10	Homo sapiens	Q9BZW7	Y2H Prey Pooling	25416956
Intra	CDC73	Q6P1J9	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	TSGA10	Homo sapiens	Q9BZW7	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	TSGA10	Homo sapiens	Q9BZW7	Y2H Array	25910212
Intra	CDC73	Q6P1J9	TSGA10	Homo sapiens	Q9BZW7	Y2H Array	25416956
Intra	CDC73	Q6P1J9	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25910212
Intra	CDC73	Q6P1J9	KASH5	Homo sapiens	Q8N6L0	Y2H Bait-Prey Pool	25910212
Intra	CDC73	Q6P1J9	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25910212
Intra	CDC73	Q6P1J9	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	CDC73	Q6P1J9	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	CDC73	Q6P1J9	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CDC73	Q6P1J9	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CDC73	Q6P1J9	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	CDC73	Q6P1J9	SETDB1	Homo sapiens	Q15047	Anti Bait CoIP	29774127
Intra	CDC73	Q6P1J9	SETDB1	Homo sapiens	Q15047	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	33961781
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	GMS	15923622
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	GMS	16024656
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	GMS	20178742
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	29774127
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	Anti Bait CoIP	15923622
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	TAP	24981860
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	Anti Tag CoIP	26496610
Intra	CDC73	Q6P1J9	LEO1	Homo sapiens	Q8WVC0	Anti Bait CoIP	19136632

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC73 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81455	HRPT2/Parafibromin Antibody (YA1200)	IHC-P	Human
HY-P81455A	HRPT2/Parafibromin Antibody (YA1200)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Hyperparathyroidism 2 With Jaw Tumors	Hyperparathyroidism-Jaw Tumor Syndrome Hpt-Jt HRPT2 Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas Parathyroid Adenoma With Cystic Changes Hereditary Hyperparathyroidism-Jaw Tumor Syndrome Hyperparathyroidism 2 Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary Familial Cystic Parathyroid Adenomatosis Hyperparathyroidism-Jaw Tumor Syndrome, Type 2 Parathyroid Adenomatosis, Familial Cystic
Hyperparathyroidism 1	Familial Isolated Hyperparathyroidism Fihp HRPT1 Hyperparathyroidism, Familial Isolated Primary Hyperparathyroidism, Familial Primary Familial Primary Hyperparathyroidism Fihpt Hyperparathyroidism, Familial, Isolated, Primary Hyperparathyroidism 3 Parathyroid Adenoma, Familial
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Ossifying Fibroma	Peripheral Ossifying Fibroma Fibro-Osteoma Fibroma Ossifying Fibroma, Ossifying
Fibroma
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Cdc73-Related Disorders
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Parathyroid Oncocytic Adenoma	Parathyroid Gland Oncocytic Adenoma
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Multiple Neoplasia 2a Multiple Neoplasia Type 2
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Fibrous Dysplasia	Fibrous Dysplasia Of Bone
Clear Cell Adenoma
Hereditary Wilms' Tumor	Hereditary Wilms Tumor Hereditary Wilms Tumour Hereditary Wilms' Tumour Wt1
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Water-Clear Cell Adenoma
Bone Benign Neoplasm
Malignant Fibrous Histiocytoma Of Bone	Malignant Fibrous Histiocytoma Of The Bone
Hypocalciuric Hypercalcemia, Familial, Type I	HHC1 Familial Hypocalciuric Hypercalcemia 1 Fhh1 Familial Benign Hypercalcemia 1 Fbh1 Hypocalciuric Hypercalcemia, Type I Fhh Type 1 Hhc Fhh Hypercalcemia, Familial Benign Hypocalciuric Hypercalcemia Type I Familial Hypocalciuric Hypercalcemia Type 1 Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Hypocalciuric Hypercalcemia Type I Familial Benign Hypercalcemia Type 1 Hypercalcemia, Familial Benign Type 1 Hypocalciuric Hypercalcemia, Familial 1 Familial Benign Hypocalciuric Hypercalcemia 1 Fbhh1
Hypocalciuric Hypercalcemia, Familial, Type Ii	HHC2 Familial Hypocalciuric Hypercalcemia 2 Fbh2 Familial Hypocalciuric Hypercalcemia Type 2 Hypocalciuric Hypercalcemia, Type Ii Fhh Type 2 Familial Benign Hypercalcemia, Type Ii Hypercalcemia, Familial Benign, Type Ii Hypocalciuric Hypercalcemia Type Ii Familial Benign Hypercalcemia, Type 2 Hypercalcemia, Familial Benign Type 2 Hypocalciuric Hypercalcemia, Familial, Type 2 Hypocalciuric Hypercalcemia, Familial 2 Familial Benign Hypercalcemia Type Ii Hypocalciuric Hypercalcemia-2
Osteitis Fibrosa	Osteitis Fibrosa Cystica Hyperparathyroid Bone Disease Osteitis Fibrosa Cystica Generalisata Von Recklinghausen'S Bone Disease Osteitis Fibrosa Disseminata
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Multiple Endocrine Neoplasia, Type Iv	Multiple Endocrine Neoplasia Type 4 MEN4 Multiple Endocrine Neoplasia 4 Neoplasia, Endocrine, Multiple, Type Iv
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Lipoadenoma
Hypocalciuric Hypercalcemia, Familial, Type Iii	HHC3 Familial Hypocalciuric Hypercalcemia 3 Fbh3 Familial Hypocalciuric Hypercalcemia Type 3 Hypercalcemia, Familial Benign, Oklahoma Type Hypocalciuric Hypercalcemia, Type Iii Fhh Type 3 Hypocalciuric Hypercalcemia Type Iii Familial Benign Hypercalcemia, Type Iii Hypercalcemia, Familial Benign, Type Iii Fbhok Familial Benign Hypercalcemia, Oklahoma Variant Familial Benign Hypercalcemia, Type 3 Hypercalcemia, Familial Benign, Type 3 Hypocalciuric Hypercalcemia, Familial, Type 3 Hypocalciuric Hypercalcemia, Familial 3 Familial Benign Hypercalcemia 3 Familial Benign Hypercalcemia Oklahoma Type Familial Benign Hypocalciuric Hypercalcemia 3 Fbhh3 Fhh3
Epulis	Epulides Gingival Polyp Polyp Of Gum
Endocrine Organ Benign Neoplasm
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02310	CDC73 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC73	VGNC	VGNC:60665
Rattus norvegicus	CDC73	RGD	RGD:1311766
Bos taurus	CDC73	VGNC	VGNC:27083
Mus musculus	CDC73	MGD	MGI:2384876
Macaca mulatta	CDC73	VGNC	VGNC:70766
Canis familiaris	CDC73	VGNC	VGNC:39011
Others	CDC73	NCBI