CSTF2 - cleavage stimulation factor subunit 2 Gene

Also Known as CstF-64

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1478

About CSTF2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,820,391-100,841,520 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

CSTF2 Products (3)

mRNA Protein Name
NM_001306206.2 NP_001293135.1 cleavage stimulation factor subunit 2 isoform 1
NM_001306209.2 NP_001293138.1 cleavage stimulation factor subunit 2 isoform 3
NM_001325.3 NP_001316.1 cleavage stimulation factor subunit 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
1741396 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10477523 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA 3'-end processing IMP
IMP: Inferred from mutant phenotype
32816001 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage body IDA
IDA: Inferred from direct assay
11598190 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
18305108 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
32816001 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTF2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (18 - 88)

CSTF2_hinge

CSTF2_hinge: Hinge domain of cleavage stimulation factor subunit 2 (111 - 192)

CSTF_C

CSTF_C: Transcription termination and cleavage factor C-terminal (531 - 574)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

cleavage stimulation factor subunit 2

  • CF-1 64 kDa subunit

CSTF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Validated Y2H
32296183
Intra
CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
CSTF2 P33240 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra
CSTF2 P33240 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 CPSF2 Homo sapiens Q9P2I0
Anti Tag CoIP
18688255
Intra
CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Array
32296183
Intra
CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Y2H Array
32296183
Intra
CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Validated Y2H
32296183
Intra
CSTF2 P33240 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
CSTF2 P33240 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
CSTF2 P33240 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Validated Y2H
32296183
Intra
CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Array
32296183
Intra
CSTF2 P33240 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra
CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Validated Y2H
32296183
Intra
CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra
CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra
CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra
CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 STH Homo sapiens Q8IWL8
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 STH Homo sapiens Q8IWL8
Validated Y2H
32296183
Intra
CSTF2 P33240 STH Homo sapiens Q8IWL8
Y2H Array
32296183
Intra
CSTF2 P33240 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
CSTF2 P33240 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 TFG Homo sapiens Q92734
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 TFG Homo sapiens Q92734
Validated Y2H
25416956
Intra
CSTF2 P33240 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra
CSTF2 P33240 TFG Homo sapiens Q92734
Y2H Array
32296183
Intra
CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
CSTF2 P33240 PARN Homo sapiens O95453
Anti Bait CoIP
20379136
Intra
CSTF2 P33240 CEACAM6 Homo sapiens P40199
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 CEACAM6 Homo sapiens P40199
Validated Y2H
32296183
Intra
CSTF2 P33240 CEACAM6 Homo sapiens P40199
Y2H Array
32296183
Intra
CSTF2 P33240 BARD1 Homo sapiens Q99728
Anti Bait CoIP
20379136
Intra
CSTF2 P33240 BARD1 Homo sapiens Q99728
Anti Bait CoIP
10477523
Intra
CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CSTF2 P33240 HGS Homo sapiens O14964
Y2H Array
25416956
Intra
CSTF2 P33240 HGS Homo sapiens O14964
Y2H Array
32296183
Intra
CSTF2 P33240 HGS Homo sapiens O14964
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Validated Y2H
32296183
Intra
CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Y2H Array
32296183
Intra
CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Validated Y2H
32296183
Intra
CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Y2H Array
32296183
Intra
CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Validated Y2H
32296183
Intra
CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Y2H Array
32296183
Intra
CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra
CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra
CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 ZNF341 Homo sapiens Q9BYN7
Validated Y2H
25416956
Intra
CSTF2 P33240 ZNF341 Homo sapiens Q9BYN7
Y2H Prey Pooling
25416956
Intra
CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
CSTF2 P33240 SPAG8 Homo sapiens Q99932
Y2H Prey Pooling
25416956
Intra
CSTF2 P33240 SPAG8 Homo sapiens Q99932
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03274 CSTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03275 CSTF2T Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21543 Cstf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28061 Cstf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CSTF2 VGNC VGNC:39683
Macaca mulatta CSTF2 VGNC VGNC:71536
Mus musculus CSTF2 MGD MGI:1343054
Rattus norvegicus CSTF2 RGD RGD:1596566
Bos taurus CSTF2 VGNC VGNC:27781
Felis catus CSTF2 VGNC VGNC:61240
Others CSTF2 NCBI