PARN - poly(A)-specific ribonuclease Gene

Also Known as DAN; DKCB6; PFBMFT4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5073

About PARN

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:14,435,701-14,630,260 (from NCBI)

This gene has 39 transcripts (splice variants), 1 gene allele, 201 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in thyroid (RPKM 11.4), testis (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

PARN Products (3)

mRNA	Protein	Name
NM_001134477.3	NP_001127949.1	poly(A)-specific ribonuclease PARN isoform 2
NM_001242992.2	NP_001229921.1	poly(A)-specific ribonuclease PARN isoform 3
NM_002582.4	NP_002573.1	poly(A)-specific ribonuclease PARN isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cation binding	IMP IMP: Inferred from mutant phenotype	15358788	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	25049417	GOA
enables poly(A)-specific ribonuclease activity	IMP IMP: Inferred from mutant phenotype	26482878	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14731398	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20932473	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	26482878	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in box H/ACA sno(s)RNA 3'-end processing	IDA IDA: Inferred from direct assay	22442037	GOA
involved in lncRNA processing	IMP IMP: Inferred from mutant phenotype	26482878	GOA
involved in miRNA catabolic process	IDA IDA: Inferred from direct assay	25049417	GOA
involved in poly(A)-dependent snoRNA 3'-end processing	IDA IDA: Inferred from direct assay	22442037	GOA
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	26482878	GOA
involved in regulation of telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	26950371	GOA
involved in telomerase RNA stabilization	IMP IMP: Inferred from mutant phenotype	26482878	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	22442037	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARN Protein Structure

CAF1

RNA_bind

0
100
200
300
400
500
600
639 a.a.

Protein Preferred Names	Protein Names
poly(A)-specific ribonuclease PARN	deadenylating nuclease

PARN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PARN	O95453	NCBP1	Homo sapiens	Q09161	Anti Bait CoIP	20379136
Intra	PARN	O95453	NCBP1	Homo sapiens	Q09161	Pull Down	20379136
Intra	PARN	O95453	BARD1	Homo sapiens	Q99728	Anti Bait CoIP	20379136
Intra	PARN	O95453	BARD1	Homo sapiens	Q99728	Pull Down	20379136
Intra	PARN	O95453	CSTF2	Homo sapiens	P33240	Anti Bait CoIP	20379136

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dyskeratosis Congenita, Autosomal Recessive 6	DKCB6 Autosomal Recessive Dyskeratosis Congenita 6 Dyskeratosis Congenita, Autosomal Recessive, 6 Dyskeratosis Congenita, Autosomal Recessive, Type 6
Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 4	PFBMFT4 Pulmonary Fibrosis, And/Or Bone Marrow Failure, Telomere-Related, 4 Fibrosis, Pulmonary, And/Or Bone Marrow Failure, Telomere-Related, Type 4
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Hoyeraal Hreidarsson Syndrome	Hoyeraal-Hreidarsson Syndrome Progressive Pancytopenia-Immunodeficiency-Cerebellar Hypoplasia Syndrome Cerebellar Hypoplasia With Pancytopenia Growth Retardation Prenatal With Progressive Pancytopenia And Cerebellar Hypoplasia
Pulmonary Fibrosis	Fibrosis Of Lung
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Rheumatoid Arthritis Interstitial Lung Disease	Rheumatoid Lung
Dyskeratosis Congenita Autosomal Recessive	Autosomal Recessive Dyskeratosis Congenita Dkcb Dyskeratosis Congenita, Autosomal Recessive
Pontocerebellar Hypoplasia, Type 7	Pontocerebellar Hypoplasia Type 7 PCH7 Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome Pontocerebellar Hypoplasia 7 Hypoplasia, Pontocerebellar, Type 7
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Revesz Syndrome	Exudative Retinopathy With Bone Marrow Failure DKCA5 Dyskeratosis Congenita, Autosomal Dominant 5 Dyskeratosis Congenita With Bilateral Exudative Retinopathy Retinopathy-Anemia-Central Nervous System Anomalies Syndrome Revesz-Debuse Syndrome Dyskeratosis Congenita, Autosomal Dominant, 5 Revesz Debuse Syndrome
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137817	BCH001	Inhibitor	98.72%	Unkown
HY-158970	Caf1-IN-1	Inhibitor	99.44%	Unkown
HY-RS10046	PARN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18630	Parn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25116	Parn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PARN	VGNC	VGNC:99534
Mus musculus	PARN	MGD	MGI:1921358
Felis catus	PARN	VGNC	VGNC:107806
Rattus norvegicus	PARN	RGD	RGD:1565449
Canis familiaris	PARN	VGNC	VGNC:53535
Others	PARN	NCBI