1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. BCH001

BCH001 

Cat. No.: HY-137817 Purity: 98.46%
Handling Instructions

BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging.

For research use only. We do not sell to patients.

BCH001 Chemical Structure

BCH001 Chemical Structure

CAS No. : 384859-58-9

Size Price Stock Quantity
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging[1].

In Vitro

BCH001 (100 nM-1 µM; for 7 days) reduces telomerase RNA component (TERC) RNA oligo-adenylation and increases steady state TERC RNA levels in PARN-mutant iPSC clones. BCH001 causes few transcriptome-wide changes and rescues other ncRNAs disrupted by PARN mutations[1].
BCH001 (1 µM, 24-72 h) has no adverse impact on cell growth, cell cycle, or apoptosis in induced pluripotent stem cells (iPSCs) from DC[1].
BCH001 inhibits ATP- and dose-dependently recombinant PAPD5 (rPAPD5) in vitro. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.34

Formula

C₂₀H₁₅F₃N₂O₅

CAS No.

384859-58-9

SMILES

O=C(C1=C(NC2=CC=CC=C2C(O)=O)C3=CC(OC(F)(F)F)=CC=C3N=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (297.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3790 mL 11.8951 mL 23.7903 mL
5 mM 0.4758 mL 2.3790 mL 4.7581 mL
10 mM 0.2379 mL 1.1895 mL 2.3790 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BCH001BCH 001BCH-001DNA/RNA SynthesisPAPD5rPAPD5PARNpolynucleotidepolymerasestelomerasetelomeredyskeratosiscongenitaDCpluripotentstemTERColigo-adenylationiPSCncRNAInhibitorinhibitorinhibit

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Product Name:
BCH001
Cat. No.:
HY-137817
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