country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

RTF1 - RTF1 homolog, Paf1/RNA polymerase II complex component Gene

Also Known as GTL7; KIAA0252

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23168

About RTF1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,417,095-41,483,563 (from NCBI)

This gene has 7 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 16.0), testis (RPKM 15.7) and 25 other tissues.

Summary

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in Other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]

RTF1 Products (1)

mRNA	Protein	Name
NM_015138.5	NP_055953.3	RNA polymerase-associated protein RTF1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	18184592	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	20178742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTF1 Protein Structure

Plus-3

0
200
400
600
710 a.a.

Protein Preferred Names	Protein Names
RNA polymerase-associated protein RTF1 homolog	Rtf1, Paf1/RNA polymerase II complex component, homolog

RTF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	TAP	24981860
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	16024656
Intra	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	16024656
Intra	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Cholestasis, Intrahepatic, Of Pregnancy, 1	ICP1 Intrahepatic Cholestasis Of Pregnancy 1 Cholestasis, Pregnancy-Related, 1 Pregnancy Related Cholestasis 1 Cholestasis Of Pregnancy, Intrahepatic 1 Obstetric Cholestasis Pregnancy-Related Cholestasis Recurrent Intrahepatic Cholestasis Of Pregnancy Cholestasis, Intrahepatic, Of Pregnancy, Type 1 Cholestasis Of Pregnancy
Hereditary Wilms' Tumor	Hereditary Wilms Tumor Hereditary Wilms Tumour Hereditary Wilms' Tumour Wt1
Malignant Fibrous Histiocytoma Of Bone	Malignant Fibrous Histiocytoma Of The Bone
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12318	RTF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22315	Rtf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28837	Rtf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RTF1	VGNC	VGNC:45787
Bos taurus	RTF1	VGNC	VGNC:34195
Felis catus	RTF1	VGNC	VGNC:64806
Mus musculus	RTF1	MGD	MGI:1309480
Macaca mulatta	RTF1	VGNC	VGNC:77119
Rattus norvegicus	RTF1	RGD	RGD:1310654
Others	RTF1	NCBI