VPS37B - VPS37B subunit of ESCRT-I Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79720

About VPS37B

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,865,330-122,896,124 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues.

Summary

Enables calcium-dependent protein binding activity. Involved in positive regulation of viral budding via host ESCRT complex. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]

VPS37B Products (1)

mRNA Protein Name
NM_024667.3 NP_078943.1 vacuolar protein sorting-associated protein 37B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
23924735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15218037 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of viral budding via host ESCRT complex IMP
IMP: Inferred from mutant phenotype
15218037 GOA
involved in viral release from host cell IMP
IMP: Inferred from mutant phenotype
15218037 GOA
Cellular Component GO Annotation Evidence References Source
part of ESCRT I complex IDA
IDA: Inferred from direct assay
18005716 GOA
part of ESCRT I complex IPI
IPI: Inferred from physical interaction
18005716 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15218037 GOA
located in endosome IDA
IDA: Inferred from direct assay
17940959 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
15218037 GOA
located in midbody IDA
IDA: Inferred from direct assay
19129479 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17940959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS37B Protein Structure

Mod_r

Mod_r: Modifier of rudimentary (Mod(r)) protein (12 - 159)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 37B

  • ESCRT-I complex subunit VPS37B

VPS37B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VPS37B Q9H9H4 QARS1 Homo sapiens P47897-2
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 QARS1 Homo sapiens P47897-2
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 VPS28 Homo sapiens Q548N1
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 VPS28 Homo sapiens Q548N1
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 PRKAA1 Homo sapiens Q13131
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 UBASH3B Homo sapiens Q8TF42
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 UBASH3B Homo sapiens Q8TF42
Y2H Array
25416956
Intra
VPS37B Q9H9H4 TSG101 Homo sapiens Q99816
Anti Tag CoIP
35271311
Intra
VPS37B Q9H9H4 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 BYSL Homo sapiens Q13895
Y2H Array
25416956
Intra
VPS37B Q9H9H4 SMARCD1 Homo sapiens Q96GM5
Y2H
21516116
Intra
VPS37B Q9H9H4 SMARCD1 Homo sapiens Q96GM5
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
VPS37B Q9H9H4 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 SH3YL1 Homo sapiens Q96HL8
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 SH3YL1 Homo sapiens Q96HL8
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 VPS28 Homo sapiens Q9UK41
Y2H
21516116
Intra
VPS37B Q9H9H4 VPS28 Homo sapiens Q9UK41
Anti Tag CoIP
35271311
Intra
VPS37B Q9H9H4 DCUN1D1 Homo sapiens Q96GG9
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 DCUN1D1 Homo sapiens Q96GG9
Y2H Array
25416956
Intra
VPS37B Q9H9H4 DCUN1D1 Homo sapiens Q96GG9
Y2H Prey Pooling
25416956
Intra
VPS37B Q9H9H4 SORBS3 Homo sapiens O60504
Y2H Array
25416956
Intra
VPS37B Q9H9H4 ERCC1 Homo sapiens P07992
Validated Y2H
25416956
Intra
VPS37B Q9H9H4 CDC73 Homo sapiens Q6P1J9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15689 VPS37B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VPS37B VGNC VGNC:107022
Rattus norvegicus VPS37B RGD RGD:1304576
Macaca mulatta VPS37B VGNC VGNC:100117
Mus musculus VPS37B MGD MGI:1916724
Felis catus VPS37B VGNC VGNC:107733
Others VPS37B NCBI