SH3YL1 - SH3 and SYLF domain containing 1 Gene

Also Known as RAY

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26751

About SH3YL1

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:218,136-264,824 (from NCBI)

This gene has 29 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 16.8), thyroid (RPKM 9.9) and 24 other tissues.

Summary

Enables Phosphatase binding activity and phosphatidylinositol binding activity. Predicted to act upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SH3YL1 Products (4)

mRNA Protein Name
NM_001159597.3 NP_001153069.1 SH3 domain-containing YSC84-like protein 1 isoform 2
NM_001282682.2 NP_001269611.1 SH3 domain-containing YSC84-like protein 1 isoform 3
NM_001282687.2 NP_001269616.1 SH3 domain-containing YSC84-like protein 1 isoform 4
NM_015677.4 NP_056492.2 SH3 domain-containing YSC84-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IDA
IDA: Inferred from direct assay
21624956 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
21624956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in ruffle membrane IDA
IDA: Inferred from direct assay
21624956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3YL1 Protein Structure

Ysc84

Ysc84: Las17-binding protein actin regulator (86 - 209)

SH3_9

SH3_9: Variant SH3 domain (290 - 340)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

SH3 domain-containing YSC84-like protein 1

  • SH3 domain containing, Ysc84-like 1

SH3YL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Y2H Array
32296183
Intra
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Y2H Prey Pooling
32296183
Intra
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Anti Tag CoIP
28514442
Intra
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7
Y2H Array
25416956
Intra
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7
Anti Tag CoIP
33961781
Intra
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Validated Y2H
32296183
Intra
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Array
25416956
Intra
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Array
32296183
Intra
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H
21516116
Intra
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
32296183
Intra
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Validated Y2H
25416956
Intra
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Y2H Array
25416956
Intra
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Y2H Prey Pooling
25416956
Intra
SH3YL1 Q96HL8 GFAP Homo sapiens P14136
Y2H Prey Pooling
25416956
Intra
SH3YL1 Q96HL8 GFAP Homo sapiens P14136
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 4

  • MGORS4

  • Meier-Gorlin Syndrome, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12849 SH3YL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SH3YL1 VGNC VGNC:77338
Felis catus SH3YL1 VGNC VGNC:65117
Mus musculus SH3YL1 MGD MGI:1346118
Rattus norvegicus SH3YL1 RGD RGD:1306440
Canis familiaris SH3YL1 VGNC VGNC:46137
Bos taurus SH3YL1 VGNC VGNC:34584
Others SH3YL1 NCBI