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VPS28 - VPS28 subunit of ESCRT-I Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51160

About VPS28

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,423,617-144,428,548 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele and 191 orthologues. Ubiquitous expression in ovary (RPKM 46.0), duodenum (RPKM 44.3) and 25 other tissues.

Summary

This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

VPS28 Products (2)

mRNA	Protein	Name
NM_016208.4	NP_057292.1	vacuolar protein sorting-associated protein 28 homolog isoform 1
NM_183057.3	NP_898880.1	vacuolar protein sorting-associated protein 28 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11134028	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	11916981	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	18077552	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	11916981	GOA
involved in positive regulation of ubiquitin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	11916981	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21757351	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT I complex	IDA IDA: Inferred from direct assay	18005716	GOA
part of ESCRT I complex	IPI IPI: Inferred from physical interaction	18005716	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18077552	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11134028	GOA
located in early endosome	IDA IDA: Inferred from direct assay	11916981	GOA
located in endosome	IDA IDA: Inferred from direct assay	11134028	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	11134028	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17940959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS28 Protein Structure

VPS28

0
100
200
221 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 28 homolog	ESCRT-I complex subunit VPS28

VPS28 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS28	Q9UK41	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	MBIP	Homo sapiens	Q9NS73-5	Validated Y2H	26871637
Intra	VPS28	Q9UK41	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-2	Y2H Array	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-2	BiFC	26871637
Intra	VPS28	Q9UK41	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	TCF12	Homo sapiens	Q99081-3	Validated Y2H	26871637
Intra	VPS28	Q9UK41	TCF12	Homo sapiens	Q99081-3	Y2H Array	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-3	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-3	Validated Y2H	26871637
Intra	VPS28	Q9UK41	CARD9	Homo sapiens	Q9H257-3	Y2H Array	26871637
Intra	VPS28	Q9UK41	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	26871637
Intra	VPS28	Q9UK41	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	26871637
Intra	VPS28	Q9UK41	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	26871637
Intra	VPS28	Q9UK41	VPS52	Homo sapiens	Q8N1B4	Y2H Array	26871637
Intra	VPS28	Q9UK41	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	SKIL	Homo sapiens	P12757	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	SKIL	Homo sapiens	P12757	Validated Y2H	26871637
Intra	VPS28	Q9UK41	SKIL	Homo sapiens	P12757	Y2H Array	26871637
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	33961781
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Pooling	19060904
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	35271311
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Array	19060904
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Validated Y2H	26871637
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	28514442
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	TSG101	Homo sapiens	Q99816	Y2H Array	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637	Validated Y2H	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637	Y2H Array	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637	BiFC	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637-3	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637-3	Validated Y2H	26871637
Intra	VPS28	Q9UK41	SMN1	Homo sapiens	Q16637-3	Y2H Array	26871637
Intra	VPS28	Q9UK41	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	26871637
Intra	VPS28	Q9UK41	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	26871637
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	26871637
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	31515488
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	26871637
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Anti Tag CoIP	33961781
Intra	VPS28	Q9UK41	VPS37B	Homo sapiens	Q9H9H4	Anti Tag CoIP	28514442
Intra	VPS28	Q9UK41	GOLGA2	Homo sapiens	Q08379	Validated Y2H	26871637
Intra	VPS28	Q9UK41	GOLGA2	Homo sapiens	Q08379	Y2H Array	26871637
Intra	VPS28	Q9UK41	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	TRIM27	Homo sapiens	P14373	Y2H Array	26871637
Intra	VPS28	Q9UK41	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	TRIM27	Homo sapiens	P14373	Validated Y2H	26871637
Intra	VPS28	Q9UK41	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	VPS28	Q9UK41	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	26871637
Intra	VPS28	Q9UK41	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	VPS28	Q9UK41	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	26871637
Intra	VPS28	Q9UK41	RASSF5	Homo sapiens	Q8WWW0-2	Validated Y2H	26871637
Intra	VPS28	Q9UK41	RASSF5	Homo sapiens	Q8WWW0-2	Y2H Prey Pooling	26871637
Intra	VPS28	Q9UK41	RASSF5	Homo sapiens	Q8WWW0-2	Y2H Array	26871637

Cross: Cross-species interaction Intra: Intraspecies interaction

VPS28 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83152	VPS28 Antibody (YA2897)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spastic Paraplegia 80, Autosomal Dominant	SPG80 Hereditary Spastic Paraplegia 80 Spastic Paraplegia 80 Autosomal Dominant Doid:0112341
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7	Ftd3 Frontotemporal Dementia, Chromosome 3-Linked Amyotrophic Lateral Sclerosis, Chmp2b-Related Chromosome 3-Linked Frontotemporal Dementia FTDALS7 Chmp2b-Related Frontotemporal Dementia Amyotrophic Lateral Sclerosis 17, Formerly Als17, Formerly Amyotrophic Lateral Sclerosis Type 17 Dtm1 Ftd-3 Ftd-Chmp2b Als17 Amyotrophic Lateral Sclerosis 17 Sclerosis, Lateral, Amyotrophic, Type 17 Dementia, Frontotemporal, Chromosome 3-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15681	VPS28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS28	MGD	MGI:1914164
Macaca mulatta	VPS28	VGNC	VGNC:79116
Canis familiaris	VPS28	VGNC	VGNC:48282
Bos taurus	VPS28	VGNC	VGNC:54396
Rattus norvegicus	VPS28	RGD	RGD:1306537
Felis catus	VPS28	VGNC	VGNC:66963
Others	VPS28	NCBI